ICAM5 Human
HEK293.
Intercellular adhesion molecule 5, ICAM5, ICAM-5, Telencephalin, telencephalin, TLN, TLCN, TLNtelencephalin, TLCNTelencephalin.
Greater than 90.0% as determined by SDS-PAGE.
Description
ICAM5 Human Recombinant produced in HEK293 is a single, glycosylated polypeptide chain containing 1052 amino acids (23-835 a.a) and having a molecular mass of 113.8kDa. ICAM5 is fused to a 239 amino acid hIgG-His-tag at C-terminus & purified by proprietary chromatographic techniques.
Product Specs
Intercellular adhesion molecule 5, ICAM5, ICAM-5, Telencephalin, telencephalin, TLN, TLCN, TLNtelencephalin, TLCNTelencephalin.
HEK293.
LFGLSAVSQE PFWADLQPRV AFVERGGSLW LNCSTNCPRP ERGGLETSLR RNGTQRGLRW LARQLVDIRE PETQPVCFFR CARRTLQARG LIRTFQRPDR VELMPLPPWQ PVGENFTLSC RVPGAGPRAS LTLTLLRGAQ ELIRRSFAGE PPRARGAVLT ATVLARREDH GANFSCRAEL DLRPHGLGLF ENSSAPRELR TFSLSPDAPR LAAPRLLEVG SERPVSCTLD GLFPASEARV YLALGDQNLS PDVTLEGDAF VATATATASA EQEGARQLVC NVTLGGENRE TRENVTIYSF PAPLLTLSEP SVSEGQMVTV TCAAGAQALV TLEGVPAAVP GQPAQLQLNA TENDDRRSFF CDATLDVDGE TLIKNRSAEL RVLYAPRLDD SDCPRSWTWP EGPEQTLRCE ARGNPEPSVH CARSDGGAVL ALGLLGPVTR ALSGTYRCKA ANDQGEAVKD VTLTVEYAPA LDSVGCPERI TWLEGTEASL SCVAHGVPPP DVICVRSGEL GAVIEGLLRV AREHAGTYRC EATNPRGSAA KNVAVTVEYG PRFEEPSCPS NWTWVEGSGR LFSCEVDGKP QPSVKCVGSG GATEGVLLPL APPDPSPRAP RIPRVLAPGI YVCNATNRHG SVAKTVVVSA ESPPEMDEST CPSHQTWLEG AEASALACAA RGRPSPGVRC SREGIPWPEQ QRVSREDAGT YHCVATNAHG TDSRTVTVGV EYRPVVAELA ASPPGGVRPG GNFTLTCRAE AWPPAQISWR APPGALNIGL SSNNSTLSVA GAMGSHGGEY ECAATNAHGR HARRITVRVA GPWLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.
Product Science Overview
ICAM-5 is a type I transmembrane glycoprotein that contains nine immunoglobulin-like C2-type domains in its extracellular region . These domains are involved in the binding interactions with other cells. The protein also has a 28 amino acid transmembrane domain and a 64 amino acid cytoplasmic domain . The extracellular domain of ICAM-5 is heavily glycosylated, which is important for its stability and function.
ICAM-5 is predominantly expressed on the surface of telencephalic neurons in the brain . It exhibits two types of adhesion activities: homophilic binding, which occurs between neurons, and heterophilic binding, which occurs between neurons and leukocytes . This dual binding capability suggests that ICAM-5 plays a significant role in neuron-neuron and neuron-immune cell interactions.
The primary function of ICAM-5 is to mediate cell-cell adhesion in the central nervous system. It is believed to be involved in the formation and maintenance of synaptic connections between neurons . Additionally, ICAM-5 may play a role in neuroinflammatory processes by interacting with microglial cells, which are the resident immune cells of the brain .
ICAM-5 has also been implicated in various neurological conditions. For instance, alterations in ICAM-5 expression have been observed in neurodegenerative diseases such as Alzheimer’s disease . This suggests that ICAM-5 could be a potential target for therapeutic interventions aimed at modulating neuroinflammation and synaptic function.
Recombinant ICAM-5 is produced using genetic engineering techniques, where the ICAM-5 gene is inserted into a host cell line, such as HEK293 cells, to produce the protein . The recombinant protein is then purified using chromatographic techniques to ensure high purity and functionality . Recombinant ICAM-5 is used in various research applications, including studies on cell adhesion, neuroinflammation, and synaptic function.
