LY86 Human
Lymphocyte Antigen 86 Human Recombinant
Cat. No.
BT3878
Source
Escherichia Coli.
Synonyms
Lymphocyte Antigen 86, MD-1 RP105-Associated, Protein MD-1, Ly-86, MMD-1, dJ80N2.1.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTeks products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
LY86 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (21-162) and having a molecular mass of 18.1kDa.
LY86 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
LY86 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
LY86 is a protein crucial for the proper display of CD180 on cell surfaces. It is abundantly present in B-cells, tonsils, and monocytes. Working in conjunction with TLR4 and CD180, LY86 contributes to the body's defense mechanism against bacterial lipopolysaccharide (LPS) by triggering an immune response and cytokine production.
Description
This product consists of a single chain of 165 amino acids (specifically, positions 21 to 162), representing the LY86 protein. Produced recombinantly in E. coli, it is non-glycosylated and has a molecular weight of 18.1 kDa. For purification and detection purposes, a 23 amino acid His-tag is attached to the N-terminus.
Physical Appearance
A clear solution that has been sterilized by filtration.
Formulation
The LY86 solution is provided at a concentration of 1mg/ml in a buffer consisting of 20mM Tris-HCl (pH 8.0), 0.4M Urea, and 10% glycerol.
Stability
For short-term storage (up to four weeks), keep the vial refrigerated at 4°C. For extended storage, freeze at -20°C. To further enhance stability during long-term storage, consider adding a carrier protein like HSA or BSA (0.1%). Repeated freezing and thawing of the product should be avoided.
Purity
SDS-PAGE analysis indicates a purity exceeding 85%.
Synonyms
Lymphocyte Antigen 86, MD-1 RP105-Associated, Protein MD-1, Ly-86, MMD-1, dJ80N2.1.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSGGGGKAW PTHVVCSDSG LEVLYQSCDP LQDFGFSVEK CSKQLKSNIN IRFGIILRED IKELFLDLAL MSQGSSVLNF SYPICEAALP KFSFCGRRKG EQIYYAGPVN NPEFTIPQGE YQVLLELYTE KRSTVACANA TIMCS
Product Science Overview
Gene and Protein Information
The LY86 gene is located on chromosome 6 and is a protein-coding gene. It is associated with several pathways, including the Toll-Like Receptor 3 (TLR3) Cascade and the innate immune system . The LY86 protein is vital for the effective surface expression of CD180, a molecule important for the immune response to bacterial lipopolysaccharide (LPS) and cytokine production .
Function and Mechanism
LY86 collaborates with TLR4 and CD180 to mediate the immune response to bacterial LPS. This interaction is essential for the production of cytokines, which are signaling molecules that help regulate the immune response . The protein is also involved in the positive regulation of the lipopolysaccharide-mediated signaling pathway .
Expression and Localization
Clinical Significance
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