CEA Human

Carcinoembryonic Antigen Human Recombinant
Cat. No.
BT4423
Source
Baculovirus Insect Cells.
Synonyms
CEACAM5, Meconium Antigen 100, Carcinoembryonic Antigen, CD66e Antigen, CD66e, Carcinoembryonic Antigen, CEA, oncofetal antigen.
Appearance
Sterile Filtered colourless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

CEA Human Recombinant is glycosylated with N-linked sugars and produced using baculovirus vectors in insect cells. CEA is a well-known tumor marker corresponding to the full length human CEA which is approximately 120,000 Dalton.

Product Specs

Introduction
Carcinoembryonic antigen (CEA) is a glycoprotein found in the digestive system of fetuses. It plays a role in cell adhesion. CEA production typically stops before birth. Elevated CEA levels are linked to various cancers, including colorectal, gastric, pancreatic, lung, and breast cancers, as well as in heavy smokers, which is why it is considered a tumor marker. However, benign conditions like smoking, infections, inflammatory bowel disease, pancreatitis, cirrhosis of the liver, and some non-cancerous tumors can also increase CEA levels. Generally, men, smokers, and older individuals tend to have higher CEA levels. CEA levels are useful for cancer screening, monitoring recurrence or spread, and assessing the effectiveness of tumor removal surgery. They can indicate treatment success, as levels should return to normal after successful therapy. Elevated CEA levels during follow-up may signal a recurrence of the tumor. The normal CEA range for non-smokers is 0.0 to 2.5 ng/ml of serum. Levels exceeding 20 ng/ml before treatment suggest potential metastasis. Benign conditions usually don't cause CEA to rise above 10 ng/ml. The carcinoembryonic antigen family, comprising 29 genes (18 of which are usually expressed), belongs to the immunoglobulin superfamily.
Description
Recombinant Human CEA is a glycosylated protein produced using baculovirus vectors in insect cells. It has N-linked sugars. This tumor marker corresponds to the full-length human CEA, with an approximate molecular weight of 120,000 Daltons.
Physical Appearance
The product is a clear and colorless solution that has been sterilized by filtration.
Formulation
The protein solution is provided in a sterile form and contains 10mM NaH2PO4 (pH 7) and 150mM NaCl.
Stability
CEA should be stored between 2-8°C. It is important to avoid freezing.
Purity
The purity of CEA is determined by SDS-PAGE and is greater than 90.0%.
Synonyms
CEACAM5, Meconium Antigen 100, Carcinoembryonic Antigen, CD66e Antigen, CD66e, Carcinoembryonic Antigen, CEA, oncofetal antigen.
Source
Baculovirus Insect Cells.

Product Science Overview

Discovery and Significance

CEA was initially identified as a tumor marker for colorectal cancer. Its discovery marked a significant milestone in cancer research, as it provided a potential biomarker for the detection and monitoring of certain types of cancer . The protein is produced in large amounts by some tumors, making it useful for monitoring cancer treatment .

Structure and Function

CEA belongs to a larger family of 12 carcinoembryonic antigen-related cell adhesion molecules (CEACAMs). These molecules have diverse functions in cell adhesion, intracellular and intercellular signaling, and during complex biological processes such as cancer progression, inflammation, angiogenesis, and metastasis . CEACAM1, CEACAM5, and CEACAM6 are now considered valid clinical biomarkers and promising therapeutic targets in various cancers, including melanoma, lung, colorectal, and pancreatic cancers .

Recombinant CEA

Recombinant CEA is produced using recombinant DNA technology, which involves inserting the CEA gene into a suitable expression system, such as bacteria or mammalian cells, to produce the protein in large quantities. This recombinant form of CEA is used in various research and clinical applications, including the development of vaccines and immunotherapies .

Clinical Applications

CEA is widely used as a biomarker in clinical settings to monitor the progression and treatment of certain cancers. Elevated levels of CEA in the blood can indicate the presence of cancer or a recurrence of the disease after treatment. It is particularly useful in monitoring colorectal cancer, but it can also be elevated in other cancers, such as breast, lung, and pancreatic cancers .

Research and Future Directions

Ongoing research aims to better understand the role of CEA and its related molecules in cancer and other diseases. The development of new molecular and biochemical tools, as well as mouse models, has enabled significant advancements in the study of the CEACAM network biology . These advancements may lead to new monitoring and targeting opportunities, improving the diagnosis and treatment of various cancers.

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