CEACAM7 Human
Greater than 90.0% as determined by SDS-PAGE.
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Description
CEACAM7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 (CEACAM7) is a member of the carcinoembryonic antigen (CEA) family, which is part of the immunoglobulin superfamily. This family consists of 12 different human CEACAMs and 5 different murine CEACAMs . CEACAM7, like other members of the CEA family, plays a significant role in various biological processes, including cell adhesion, intracellular and intercellular signaling, and immune responses .
The carcinoembryonic antigen (CEA) was first identified as a tumor marker for colorectal cancer in the 1960s . Subsequent research led to the discovery of a larger family of related molecules, including CEACAM7. CEACAM7 is a glycoprotein that is primarily expressed on the surface of epithelial cells in the colon and rectum . It consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail, which are involved in mediating cell-cell adhesion and signaling .
CEACAM7 is involved in several key biological processes:
- Cell Adhesion: CEACAM7 mediates homophilic and heterophilic cell-cell adhesion, which is crucial for maintaining tissue architecture and integrity .
- Immune Response: CEACAM7 plays a role in the immune response by acting as a receptor for various bacterial and viral pathogens . It is involved in the recognition and internalization of pathogens, as well as the activation of immune cells .
- Cancer Progression: CEACAM7 is implicated in cancer progression and metastasis. Its expression is often altered in various cancers, including colorectal, lung, and pancreatic cancers . CEACAM7 can influence tumor cell behavior, including proliferation, migration, and invasion .
CEACAM7 is considered a potential biomarker for cancer diagnosis and prognosis . Its expression levels can be used to monitor disease progression and response to therapy. Additionally, CEACAM7 is being explored as a therapeutic target for cancer treatment . Targeting CEACAM7 with specific antibodies or small molecules could potentially inhibit tumor growth and metastasis .
