CEACAM21 Human

CEACAM21 is a protein-coding gene that encodes a cell surface glycoprotein. The structure of CEACAM21 includes an extracellular domain, a transmembrane domain, and a cytoplasmic domain. The extracellular domain is responsible for mediating cell-cell adhesion through homophilic and heterophilic interactions .

CEACAM21 is expressed in various tissues, including epithelial cells and immune cells. Its expression can be modulated by different factors, such as cytokines and bacterial infections. For instance, certain pathogens like non-typable Haemophilus influenzae and Moraxella catarrhalis can increase the expression of CEACAMs in bronchial epithelial cells .

CEACAM21, like other members of the CEACAM family, is associated with several diseases. It has been linked to conditions such as ethmoid sinus inverted papilloma and ethmoidal sinus benign neoplasm . Additionally, CEACAMs are known to play a role in cancer biology. They can influence tumor progression and immune responses, making them potential targets for cancer therapy .

The clinical significance of CEACAM21 lies in its potential as a biomarker for certain diseases and its role in immune modulation. Understanding the regulation and function of CEACAM21 can provide insights into its role in disease mechanisms and aid in the development of therapeutic strategies.

Research on CEACAM21 and other CEACAMs continues to uncover their complex roles in health and disease. The therapeutic potential of targeting CEACAMs in cancer and other diseases is an area of active investigation. By modulating CEACAM expression or function, it may be possible to develop new treatments for various conditions .