CEACAM8 Human

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 Human Recombinant
Cat. No.
BT5092
Source

Sf9, Baculovirus cells.

Synonyms

Carcinoembryonic antigen-related cell adhesion molecule 8, CD67 antigen, Carcinoembryonic antigen CGM6, Non-specific cross-reacting antigen NCA-95, CD66b, CGM6, CD67, NCA-95, CEACAM8

Appearance

Sterile filtered colorless solution.

Purity

Greater than 95.0% as determined by SDS-PAGE.

Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

CEACAM8 Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 292 amino acids (35-320 a.a) and having a molecular mass of 32.3kDa.
CEACAM8 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 (CEACAM8) is a cell surface glycoprotein involved in calcium-independent cell adhesion. It mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. CEACAM8 plays a crucial role in cell migration, cell adhesion, and pathogen binding. It is primarily expressed on the surface of human peripheral blood eosinophils isolated from healthy individuals and serves as a granulocyte marker.
Description
CEACAM8 Human, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain containing 292 amino acids (35-320 a.a) with a molecular mass of 32.3 kDa. It is fused to a 6 amino acid His-tag at the C-terminus and purified using proprietary chromatographic techniques.
Physical Appearance
Sterile filtered colorless solution.
Formulation
The CEACAM8 solution (1mg/ml) is supplied in Phosphate-Buffered Saline (pH 7.4) with 10% glycerol.
Stability
For short-term storage (2-4 weeks), store at 4°C. For extended periods, store frozen at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Greater than 95.0% purity as determined by SDS-PAGE.
Synonyms

Carcinoembryonic antigen-related cell adhesion molecule 8, CD67 antigen, Carcinoembryonic antigen CGM6, Non-specific cross-reacting antigen NCA-95, CD66b, CGM6, CD67, NCA-95, CEACAM8

Source

Sf9, Baculovirus cells.

Amino Acid Sequence

QLTIEAVPSN AAEGKEVLLL VHNLPQDPRG YNWYKGETVD ANRRIIGYVI SNQQITPGPA YSNRETIYPN ASLLMRNVTR NDTGSYTLQV IKLNLMSEEV TGQFSVHPET PKPSISSNNS NPVEDKDAVA FTCEPETQNT TYLWWVNGQS LPVSPRLQLS NGNRTLTLLS VTRNDVGPYE CEIQNPASAN FSDPVTLNVL YGPDAPTISP SDTYYHAGVN LNLSCHAASN PPSQYSWSVN GTFQQYTQKL FIPNITTKNS GSYACHTTNS ATGRNRTTVR MITVSDHHHH HH

Product Science Overview

Structure and Function

CEACAM8 is primarily expressed on the surface of granulocytes, a type of white blood cell involved in the immune response. It mediates homophilic cell adhesion in a calcium-independent manner, meaning it can bind to itself without the need for calcium ions . This adhesion property is crucial for the regulation of immune cell interactions and responses.

The protein is involved in various biological processes, including:

  • Innate Immune System: CEACAM8 participates in the body’s first line of defense against pathogens.
  • Cell Surface Interactions: It plays a role in interactions at the vascular wall, which is essential for immune surveillance and response .
Clinical Significance

CEACAM8 has been associated with several diseases, including lung cancer and androgen insensitivity syndrome . Its expression levels can be indicative of certain pathological conditions, making it a potential biomarker for disease diagnosis and prognosis.

In cancer research, CEACAM8, along with other CEACAM family members, has been studied for its role in cancer progression and metastasis. These molecules are involved in cell adhesion, intracellular and intercellular signaling, and complex biological processes such as inflammation and angiogenesis .

Recombinant CEACAM8

Recombinant CEACAM8 refers to the protein produced through recombinant DNA technology, which involves inserting the gene encoding CEACAM8 into a suitable expression system, such as bacteria or mammalian cells. This technology allows for the large-scale production of the protein for research and therapeutic purposes.

Recombinant CEACAM8 is used in various applications, including:

  • Research: Studying the protein’s structure, function, and role in disease.
  • Therapeutics: Developing targeted therapies for diseases associated with CEACAM8 expression.

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