CEACAM1 Human
Description
CEACAM1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 405 amino acids (35-428 a.a.) and having a molecular mass of 44.6kDa (Molecular size on SDS-PAGE will appear at approximately 40-70 kDa). CEACAM1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
CEACAM1 is a glycoprotein that mediates cell adhesion via both homophilic (binding to itself) and heterophilic (binding to other proteins) interactions . It plays a crucial role in various biological processes, including:
- Cell Adhesion: CEACAM1 facilitates cell-cell adhesion, which is essential for maintaining tissue architecture and integrity .
- Immune Response: It is involved in the regulation of immune responses, acting as a co-inhibitory molecule that can modulate T-cell responses .
- Angiogenesis: CEACAM1 is associated with early stages of angiogenesis, regulating the proliferation, migration, and differentiation of endothelial cells .
CEACAM1 has been identified as a prognostic marker in various cancers, including colorectal, lung, and pancreatic cancers . Its expression is often altered in tumor cells, and it can influence tumor progression and metastasis . The protein’s role in cancer has made it a target for therapeutic interventions and a biomarker for disease monitoring .
Recombinant CEACAM1 is produced using recombinant DNA technology, which involves inserting the gene encoding CEACAM1 into a suitable expression system, such as bacteria or mammalian cells. This allows for the large-scale production of the protein for research and therapeutic purposes.
Research on CEACAM1 has provided insights into its diverse functions and its role in disease. Studies have shown that CEACAM1 expression can be modulated by various factors, including cytokines and bacterial infections . For example, non-typable Haemophilus influenzae and Moraxella catarrhalis can increase CEACAM1 expression in bronchial epithelial cells .
