TGIF2LX Human

TGFB-Induced Factor Homeobox 2-Like, X-Linked Human Recombinant
Cat. No.
BT16031
Source
Escherichia Coli.
Synonyms
Homeobox protein TGIF2LX, TGF-beta-induced transcription factor 2-like protein,
TGFB-induced factor 2-like protein, X-linked, TGIF-like on the X, TGIF2LX, TGIFLX, TGFB-Induced Factor Homeobox 2-Like, X-Linked.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
Quick Inquiry

Description

TGIF2LX Human Recombinant produced in E. coli is. a single polypeptide chain containing 264 amino acids (1-241) and having a molecular mass of 29.1kDa.
TGIF2LX is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
As a member of the TALE/TGIF homeobox family of transcription factors, TGFB-Induced Factor Homeobox 2-Like, X-Linked (TGIF2LX) is involved in spermatogenesis. This protein has a homolog located on the Y chromosome within the male-specific region, within a block of sequence resulting from a large X-to-Y transposition.
Description
Recombinant human TGIF2LX, expressed in E. coli, is a single polypeptide chain with a molecular weight of 29.1 kDa. The protein consists of 264 amino acids, including amino acids 1-241 of the TGIF2LX sequence, and a 23 amino acid His-tag fused to the N-terminus. Purification is achieved using proprietary chromatographic techniques.
Physical Appearance
A clear solution that has undergone sterile filtration.
Formulation
The TGIF2LX solution is provided at a concentration of 0.5 mg/ml and is formulated in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.2 M NaCl, 50% glycerol, and 1 mM DTT.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to store the product frozen at -20°C. To further enhance long-term stability, the addition of a carrier protein (0.1% HSA or BSA) is recommended. Repeated freezing and thawing of the product should be avoided.
Purity
Purity of TGIF2LX is determined to be greater than 85% based on SDS-PAGE analysis.
Synonyms
Homeobox protein TGIF2LX, TGF-beta-induced transcription factor 2-like protein,
TGFB-induced factor 2-like protein, X-linked, TGIF-like on the X, TGIF2LX, TGIFLX, TGFB-Induced Factor Homeobox 2-Like, X-Linked.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMEAAADG PAETQSPVEK DSPAKTQSPA QDTSIMSRNN ADTGRVLALP EHKKKRKGNL PAESVKILRD WMYKHRFKAY PSEEEKQMLS EKTNLSLLQI SNWFINARRR ILPDMLQQRR NDPIIGHKTG KDAHATHLQS TEASVPAKSG PSGPDNVQSL PLWPLPKGQM SREKQPDPES APSQKLTGIA QPKKKVKVSV TSPSSPELVS PEEHADFSSF LLLVDAAVQR AAELELEKKQ EPNP.

Product Science Overview

Introduction

The TGFB-Induced Factor Homeobox 2-Like, X-Linked (TGIF2LX) is a member of the TALE/TGIF homeobox family of transcription factors. This gene is specifically expressed in the testis and is believed to play a significant role in spermatogenesis . The human recombinant form of this protein is utilized in various research and clinical applications.

Gene and Protein Structure

The TGIF2LX gene is located on the X chromosome and encodes a protein that contains a homeobox DNA-binding domain . This domain is crucial for the protein’s function as a transcription factor, allowing it to bind to specific DNA sequences and regulate the expression of target genes.

Function and Expression

TGIF2LX is primarily expressed in adult testis, suggesting its involvement in the regulation of genes essential for spermatogenesis . The protein may have a transcriptional role in the testis, influencing the development and function of sperm cells .

Evolutionary Significance

A homolog of the TGIF2LX gene is found within the male-specific region of the Y chromosome, indicating that this gene may have arisen from a large X-to-Y transposition event . This evolutionary event highlights the gene’s significance in male reproductive biology.

Clinical Relevance

Mutations or dysregulation of the TGIF2LX gene have been associated with certain diseases, including autosomal recessive pyridoxine-refractory sideroblastic anemia . Understanding the function and regulation of this gene could provide insights into the mechanisms underlying these conditions and potentially lead to new therapeutic approaches.

Research Applications

The human recombinant form of TGIF2LX is used in various research studies to investigate its role in gene regulation and spermatogenesis. By studying the recombinant protein, researchers can gain a deeper understanding of its function and potential implications in reproductive health and disease.

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.