TGFBRAP1 Human

Transforming Growth Factor Beta Receptor Associated Protein 1 (TGFBRAP1) is a crucial component in the signaling pathways of the Transforming Growth Factor Beta (TGF-β) family. TGF-β is a multifunctional cytokine that regulates various cellular processes, including cell growth, differentiation, apoptosis, and immune responses . TGFBRAP1 plays a significant role in mediating the effects of TGF-β by interacting with its receptors and other signaling molecules.

TGFBRAP1 is a protein that interacts with the TGF-β receptors, facilitating the downstream signaling cascade. This protein is involved in the recruitment and activation of SMAD proteins, which are critical transcription factors in the TGF-β signaling pathway . The proper functioning of TGFBRAP1 is essential for the regulation of cellular processes and maintaining cellular homeostasis.

Human recombinant TGFBRAP1 is produced using genetic engineering techniques. The gene encoding TGFBRAP1 is cloned into an expression vector, which is then introduced into a suitable host cell, such as Escherichia coli or mammalian cells. The host cells are cultured under optimal conditions to express the recombinant protein, which is subsequently purified using various chromatographic techniques .

Recombinant TGFBRAP1 is widely used in research to study the TGF-β signaling pathway and its implications in various diseases, including cancer, fibrosis, and autoimmune disorders . By understanding the role of TGFBRAP1 in these processes, researchers can develop targeted therapies to modulate TGF-β signaling for therapeutic purposes.