PDCD4 Human
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Description
Product Specs
Product Science Overview
The PDCD4 gene is located on chromosome 10q24 . The protein encoded by this gene is involved in inhibiting translation initiation by binding to the eukaryotic translation initiation factor 4A1 (eIF4A1) and preventing its interaction with RNA . This inhibition is crucial for controlling protein synthesis and, consequently, cell growth and proliferation.
PDCD4 functions as a tumor suppressor by inhibiting neoplastic transformation and promoting apoptosis . It modulates the activation of JUN kinase and down-regulates the expression of MAP4K1, which are important in driving invasion and metastasis . By hindering the interaction between eIF4A1 and eIF4G, PDCD4 inhibits the helicase activity of eIF4A, thereby preventing the unwinding of RNA necessary for translation initiation .
PDCD4 has been extensively studied for its role in various cancers. Down-regulation of PDCD4 is associated with the progression of several types of solid tumors, including head and neck, breast, digestive system, and urinary system cancers . Reduced expression of PDCD4 is linked to poor prognosis and shorter overall survival in cancer patients . Its clinical significance as a prognostic marker for solid tumors is being explored, with evidence suggesting its potential utility in predicting cancer outcomes .
Recombinant PDCD4 refers to the protein produced through recombinant DNA technology, which involves inserting the PDCD4 gene into an expression system to produce the protein in vitro. This recombinant protein is used in research to study its function, mechanism, and potential therapeutic applications. By using recombinant PDCD4, researchers can investigate its role in apoptosis, cancer progression, and its interactions with other cellular proteins.
Research on PDCD4 continues to uncover its multifaceted role in cancer biology. Studies have shown that up-regulation of PDCD4 can induce apoptosis in cancer cells, making it a potential target for cancer therapy . Additionally, understanding the molecular mechanisms by which PDCD4 regulates translation initiation and apoptosis can lead to the development of novel therapeutic strategies aimed at restoring its function in cancer cells.
