PDCD5 Human
Programmed Cell Death-5 Human Recombinant
Cat. No.
BT7998
Source
Escherichia Coli.
Synonyms
Programmed cell death protein 5, TF-1 cell apoptosis-related protein 19, Protein TFAR19, PDCD5, TFAR19, MGC9294.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
PDCD5 Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 125 amino acids and having a molecular mass of 14 kDa.
Product Specs
Introduction
PDCD5 is expressed in tumor cells during apoptosis regardless of the stimuli that initiated the process. Before apoptosis induction, PDCD5 is found in both the nucleus and cytoplasm. Once apoptosis begins, PDCD5 levels increase, and the protein relocates from the cytoplasm, accumulating in the nucleus. PDCD5 protein has a stable helical core structure consisting of a triple-helix bundle and two separate terminal regions. PDCD5 is a significant novel protein that regulates both apoptotic and non-apoptotic programmed cell death. It plays a role in the process of apoptosis and is important in regulating apoptotic processes in gastric cancer cells and gastric tumors. Additionally, PDCD5 is involved in the pathogenesis of rheumatoid arthritis. The -27G/-11A SNP is associated with reduced PDCD5 promoter activity and increased susceptibility to chronic myelogenous leukemia. The PDCD5 gene may be a target gene controlled by important apoptosis-related transcriptional factors during cell apoptosis.
Description
Recombinant PDCD5, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 125 amino acids. It has a molecular weight of 14 kDa.
Physical Appearance
Sterile, colorless solution.
Formulation
PDCD5 protein solution is supplied in 1x PBS at pH 7.4.
Stability
For short-term storage (2-4 weeks), store the solution at 4°C. For long-term storage, freeze the solution at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity is greater than 95.0% as determined by SDS-PAGE analysis.
Synonyms
Programmed cell death protein 5, TF-1 cell apoptosis-related protein 19, Protein TFAR19, PDCD5, TFAR19, MGC9294.
Source
Escherichia Coli.
Amino Acid Sequence
MADEELEALR RQRLAELQAK HGDPGDAAQQ EAKHRGAEMR NSILAQVLDQ SARARLSNLA LVKPEKTKAV ENYLIQMARY GQLSEKVSEQ GLIEILKKVS QQTEKTTTVK LNRRKVMDSD EDDDY.
Product Science Overview
Role in Apoptosis
PDCD5 is primarily known for its role in promoting apoptosis, a form of programmed cell death crucial for maintaining tissue homeostasis and eliminating damaged or infected cells . Apoptosis is a highly regulated process, and PDCD5 has been shown to enhance this process in various cancer cells . The protein is widely expressed in various cell lines, indicating its regulatory role in both pathological and physiological processes .
Expression in Cancer
Decreased expression of PDCD5 has been observed in several human tumors, including breast cancer, gastric cancer, astrocytic glioma, chronic myelogenous leukemia, and hepatocellular carcinoma . This suggests that PDCD5 may act as a tumor suppressor, and its reduced expression could contribute to tumorigenesis .
Mechanisms and Functions
Recent studies have highlighted several functions and mechanisms of PDCD5 in cancer cells:
- Paraptosis: PDCD5 is involved in paraptosis, a type of programmed cell death distinct from apoptosis .
- Cell Cycle Regulation: PDCD5 plays a role in regulating the cell cycle, ensuring that cells do not proliferate uncontrollably .
- Immunoregulation: PDCD5 has been implicated in the immune response, potentially influencing how the body detects and responds to cancer cells .
- Viral Infection: PDCD5 may also play a role in the body’s response to viral infections .
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