CHMP2A Human
Description
The CHMP2A is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
CHMP2A plays a pivotal role in the formation of multivesicular bodies (MVBs), which are essential for the sorting and trafficking of cellular cargo destined for degradation . The ESCRT-III complex, which includes CHMP2A, is responsible for the formation of intraluminal vesicles within endosomes, leading to the creation of MVBs . This process ensures the proper removal of obsolete or damaged cellular components, contributing to cellular maintenance and homeostasis .
The molecular mechanisms underlying CHMP2A function involve its interaction with other ESCRT-III components, orchestrating a finely-tuned process of cargo recognition, membrane deformation, and vesicle scission . This dynamic interplay is crucial for the regulation of various signaling pathways, impacting cellular responses to external stimuli .
Recombinant human CHMP2A is typically expressed in Escherichia coli and is purified using conventional chromatography techniques . The protein is characterized by its structural intricacies and is classified as a member of the AAA ATPase family . It is a single, non-glycosylated polypeptide chain containing 242 amino acids and has a molecular mass of approximately 27.2 kDa .
CHMP2A is involved in several critical cellular processes, including:
- Endosomal Sorting: CHMP2A participates in the sorting and trafficking of endosomal cargo proteins into MVBs .
- Membrane Dynamics: The protein plays a role in membrane deformation and vesicle scission, essential for the formation of intraluminal vesicles .
- Degradation Pathways: CHMP2A is involved in the degradation of surface receptor proteins and the formation of endocytic MVBs .
Anomalies in CHMP2A expression or function have been associated with various diseases, highlighting its significance in maintaining cellular health . Mutations in CHMP2A have been linked to neurodegenerative disorders, including frontotemporal dementia (FTD) . Research suggests that dysregulation of the ESCRT machinery, including CHMP2A, may contribute to the pathological accumulation of protein aggregates seen in FTD and other related conditions .
The versatility of CHMP2A extends beyond its fundamental cellular functions, making it a promising candidate for biomedical applications . In diagnostic development, CHMP2A can serve as a potential biomarker for conditions associated with ESCRT dysfunction, aiding in the early detection and monitoring of diseases such as FTD .
