PTX3 Human
Description
Recombinant Human PTX3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 401 amino acids (18-381 a.a) and having a molecular mass of 44.4 kDa.
PTX3 is fused to a 37 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
Product Specs
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMENS DDYDLMYVNL DNEIDNGLHP TEDPTPCDCG QEHSEWDKLF IMLENSQMRE RMLLQATDDV LRGELQRLRE ELGRLAESLA RPCAPGAPAE ARLTSALDEL LQATRDAGRR LARMEGAEAQ RPEEAGRALA AVLEELRQTR ADLHAVQGWA ARSWLPAGCE TAILFPMRSK KIFGSVHPVR PMRLESFSAC IWVKATDVLN KTILFSYGTK RNPYEIQLYL SYQSIVFVVG GEENKLVAEA MVSLGRWTHL CGTWNSEEGL TSLWVNGELA ATTVEMATGH IVPEGGILQI GQEKNGCCVG GGFDETLAFS GRLTGFNIWD SVLSNEEIRE TGGAESCHIR GNIVGWGVTE IQPHGGAQYV S.
Product Science Overview
Pentraxin-3 (PTX3) is a member of the pentraxin superfamily, which includes evolutionarily conserved proteins involved in innate immunity and inflammation. PTX3 is classified as a long pentraxin, distinguishing it from the short pentraxins such as C-reactive protein (CRP) and serum amyloid P component (SAP). PTX3 was first identified in the early 1990s as an inducible gene by interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α) .
PTX3 is a glycoprotein composed of 381 amino acids and has a molecular weight of approximately 45 kDa. It contains a unique N-terminal domain and a C-terminal pentraxin domain, which is characteristic of the pentraxin family. PTX3 is produced by various cell types, including endothelial cells, fibroblasts, mononuclear phagocytes, and dendritic cells, in response to primary pro-inflammatory signals and microbial recognition .
PTX3 plays a crucial role in the regulation of innate immunity, inflammation, and tissue remodeling. It acts as a soluble pattern recognition molecule, recognizing and binding to microbial moieties and damaged tissues. This binding facilitates the activation of the complement system, opsonization of pathogens, and regulation of inflammation. PTX3 is also involved in tissue repair and remodeling, making it a multifunctional protein with significant implications in various physiological and pathological processes .
PTX3 has emerged as a valuable biomarker for various diseases due to its role in inflammation and immune responses. Elevated levels of PTX3 have been observed in conditions such as cardiovascular diseases, infections, and cancer. For instance, PTX3 levels are significantly correlated with the severity of lower respiratory tract infections (LRTIs) in children, making it a potential diagnostic and prognostic marker for these infections . Additionally, PTX3 is being investigated for its role in bone homeostasis and pathology, further highlighting its clinical relevance .
Human recombinant PTX3 is produced using recombinant DNA technology, which involves the insertion of the PTX3 gene into an expression system, such as bacteria or mammalian cells, to produce the protein in large quantities. Recombinant PTX3 is used in research to study its biological functions and potential therapeutic applications. It provides a consistent and reliable source of the protein for experimental purposes, enabling scientists to explore its role in various diseases and develop targeted therapies.
