PTX2 Mouse

Pentraxin-2, also known as Serum Amyloid P Component (SAP), is a member of the pentraxin family of proteins, which also includes C-reactive protein (CRP) and pentraxin-3 . These proteins are characterized by their pentameric structure and are involved in various immune responses .

Initially discovered and characterized as serum amyloid P due to its isolation from amyloid deposits in humans, Pentraxin-2 was later found to be present in the sera from circulating blood . This led to its designation as SAP. The protein is a universal non-fibrillar component of amyloid deposits, which are extracellular deposits of insoluble protein fibrils resulting from protein misfolding .

Pentraxin-2 plays a crucial role in regulating wound healing and fibrosis . It is closely related to PTX-1 (C-reactive protein), and both are short pentraxins synthesized by the liver . The protein has multiple biological properties and functions, including binding to various ligands and participating in the clearance of apoptotic cells .

Recombinant Mouse Pentraxin-2 is produced using a mouse myeloma cell line, NS0-derived mouse Pentraxin-2/SAP protein . The recombinant protein is typically purified to a high degree of purity (>90%) and is used in various research applications . It is often formulated in a lyophilized form and can be reconstituted in sterile PBS for use in experiments .

Recombinant Pentraxin-2 is used in various research areas, including studies on amyloidosis, fibrosis, and immune responses . Its binding ability is often measured using functional ELISA assays, where it can bind to recombinant human CD32a Fc Chimera . The protein’s role in regulating fibrosis makes it a potential therapeutic target for diseases such as idiopathic pulmonary fibrosis (IPF) .