Prealbumin Human
Human serum.
TTHY, TTR, ATTR, TBPA, Transthyretin, Prealbumin, PALB, HsT2651TTHY, TTR, ATTR, TBPA, Transthyretin, Prealbumin, PALB, HsT2651.
Sterile Filtered White lyophilized (freeze-dried) powder.
Greater than 96.0%.
Description
Human Transthyretin dimer protein produced in Human plasma having a molecular mass of 30kD. Under certain conditions it may be shown as a monomer (15kD) or a tetramer (60kD).
Product Specs
Prealbumin, also known as transthyretin, is a protein responsible for transporting thyroid hormones and vitamin A in the body. Primarily produced by the liver, it plays a crucial role in thyroid hormone delivery to the brain and overall nutrient transport. Mutations in the prealbumin gene can lead to amyloid protein deposits, potentially causing conditions like amyloidotic polyneuropathy and cardiomyopathy. Due to its short half-life, prealbumin serves as a valuable marker for assessing nutritional status and identifying protein-energy malnutrition.
This product consists of a human transthyretin dimer protein, derived from human plasma. Its molecular weight is typically 30kD, but may present as a 15kD monomer or a 60kD tetramer under certain conditions.
This product comes in the form of a sterile, white powder that has been lyophilized (freeze-dried).
This protein solution was lyophilized after being filtered through a 0.2 µm filter. The solution initially contained 20mM ammonium bicarbonate (NH4HCO3).
For optimal reconstitution, it is advised to dissolve the lyophilized Prealbumin Human in a phosphate buffer solution with a pH greater than 7, containing 0.15M NaCl.
While Prealbumin Human remains stable at room temperature for up to 3 weeks, it is recommended to store it between 2-8°C for long-term preservation.
The purity of this product exceeds 96.0%.
The source material for this product has undergone rigorous testing and is certified free of antibodies for HIV-1, HIV-2, HCV, HBSAG, Parvovirus B19, and Syphilis. Additionally, PCR tests confirm the absence of HIV, HBV, and HCV.
TTHY, TTR, ATTR, TBPA, Transthyretin, Prealbumin, PALB, HsT2651TTHY, TTR, ATTR, TBPA, Transthyretin, Prealbumin, PALB, HsT2651.
Human serum.
Product Science Overview
Transthyretin is a tetrameric protein, meaning it consists of four identical subunits. Each subunit is a 127-residue polypeptide rich in beta-sheet structures. The association of two monomers forms an extended beta sandwich, and further association of two of these dimers in a face-to-face fashion produces the homotetrameric structure. This structure creates two thyroxine binding sites per tetramer .
In the bloodstream, TTR functions alongside two other thyroid hormone-binding proteins: thyroxine-binding globulin (TBG) and albumin. While TBG has the highest binding strength but the lowest plasma concentration, TTR has a lower binding strength but a higher plasma concentration. In the cerebrospinal fluid, TTR is the primary carrier of T4 .
Mutations in the TTR gene are associated with inherited transthyretin amyloidosis (ATTRv), a progressive and debilitating disease characterized by the misfolding of TTR and aggregation as amyloid fibrils. This condition predominantly leads to cardiomyopathy or polyneuropathy, depending on the specific TTR mutation. Transthyretin amyloid cardiomyopathy can also occur as an age-related disease caused by the misfolding of wild-type TTR .
Apart from its transport role, there is growing evidence that TTR may have a role in neuroprotection and the promotion of neurite outgrowth in response to injury. Studies using animal model systems in which TTR has been disrupted via gene knockout are contributing to our understanding of TTR’s functions .
TTR was originally called prealbumin because it migrated faster than albumin on electrophoresis gels. However, this name was considered misleading as it is not a synthetic precursor of albumin. The alternative name, transthyretin, was proposed by DeWitt Goodman in 1981 to reflect its function of transporting thyroxine and retinol .
