CNPY1 Human

Canopy FGF Signaling Regulator 1 Human Recombinant
Cat. No.
BT3890
Source
Escherichia Coli.
Synonyms
Protein canopy homolog 1, CNPY1.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

CNPY1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 115 amino acids (1-92 a.a) and having a molecular mass of 13.3kDa.
CNPY1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
Canopy FGF Signaling Regulator 1, also known as CNPY1, is a protein found in zebrafish that is primarily expressed in the midbrain-hindbrain boundary. This protein plays a role in FGF signaling pathways by binding to FGFR1.
Description
This product consists of a recombinant human CNPY1 protein produced in E. coli. It is a single, non-glycosylated polypeptide chain that contains 115 amino acids (amino acids 1-92 of the CNPY1 sequence) with a 23 amino acid His-tag fused to the N-terminus. This results in a protein with a molecular mass of 13.3 kDa. The protein has been purified using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless, and sterile-filtered solution.
Formulation
The CNPY1 protein is provided at a concentration of 0.5 mg/ml in a buffer solution containing 20 mM Tris-HCl (pH 8.0), 0.15 M NaCl, 10% glycerol, and 1 mM DTT.
Stability
For short-term storage (up to 2-4 weeks), the product can be stored at 4°C. For long-term storage, it is recommended to store the product frozen at -20°C. Adding a carrier protein such as 0.1% HSA or BSA is recommended for long-term storage. Repeated freezing and thawing of the product should be avoided.
Purity
The purity of the CNPY1 protein is greater than 90% as determined by SDS-PAGE analysis.
Synonyms
Protein canopy homolog 1, CNPY1.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMNDYKLE EDPVTKERTF KRFAPRKGDK IYQEFKKLYF YSDAYRPLKF ACETIIEEYE DEISSLIAQE THYLADKLCS EKSDLCETSA NHTEL.

Product Science Overview

Gene and Protein Structure

The CNPY1 gene is located on chromosome 7 in humans and is a protein-coding gene . The gene is highly conserved across different species, including zebrafish, mice, and humans . The protein encoded by this gene contains a domain known as the DUF3456 domain, which is involved in its regulatory functions .

Function and Mechanism

CNPY1 is primarily involved in the FGF signaling pathway. FGF signaling is critical for numerous biological processes, including cell growth, differentiation, and tissue repair. CNPY1 acts as a regulator by binding to the FGF receptor 1 (FGFR1) and modulating its activity . This interaction is vital for maintaining the proper balance of FGF signaling, which is necessary for normal development and cellular homeostasis.

Biological Significance

The regulation of FGF signaling by CNPY1 has significant implications for various developmental processes. For instance, it is expressed in the midbrain-hindbrain boundary in zebrafish, indicating its role in brain development . Additionally, CNPY1 has been associated with certain diseases, such as orofacial cleft 2 and infantile-onset distal myopathy, highlighting its importance in human health .

Research and Applications

Research on CNPY1 has provided valuable insights into its function and potential therapeutic applications. The recombinant form of CNPY1, known as Human Recombinant Canopy FGF Signaling Regulator 1, is used in various experimental settings to study its role in FGF signaling and its potential as a therapeutic target. Understanding the mechanisms by which CNPY1 regulates FGF signaling can lead to the development of novel treatments for diseases associated with dysregulated FGF signaling.

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