SCGB1D1 Human
Description
Product Specs
Product Science Overview
The SCGB1D1 protein is composed of 90 amino acids in its precursor form, with a calculated molecular mass of approximately 9.9 kDa. Upon removal of the N-terminal signal sequence, the mature protein consists of 69 amino acids and has a predicted molecular mass of 7.6 kDa . This protein is known to form heterodimers and is a significant component of human tears .
SCGB1D1 is believed to bind androgens and other steroids, and it may also bind estramustine, a chemotherapeutic agent used for prostate cancer . The protein’s expression is thought to be regulated by steroid hormones, suggesting a role in endocrine-responsive tissues .
SCGB1D1 is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland . In humans, lipophilins, including SCGB1D1, are widely expressed in normal tissues, particularly in endocrine-responsive organs . The protein’s ability to bind and concentrate estramustine highlights its potential importance in prostate cancer treatment .
Diseases associated with SCGB1D1 include Diaphragmatic Eventration and Linear Skin Defects with Multiple Congenital Anomalies 1 . The protein’s role in binding steroids and chemotherapeutic agents underscores its potential therapeutic applications, particularly in the context of hormone-responsive cancers .
Recombinant SCGB1D1 is produced using recombinant DNA technology, which involves inserting the SCGB1D1 gene into a suitable expression system, such as bacteria or yeast, to produce the protein in large quantities. This recombinant protein can be used in various research applications, including studies on steroid hormone regulation, protein-protein interactions, and potential therapeutic uses .
