TCEAL3 Human

TCEA3 is a protein-coding gene that encodes a protein involved in the transcription process. The primary function of TCEA3 is to assist RNA polymerase II in overcoming transcriptional arrest. During transcription, RNA polymerase II can sometimes pause or stall due to various obstacles, such as DNA damage or tightly bound nucleosomes. TCEA3 helps to resolve these pauses by promoting the cleavage of the nascent RNA transcript, allowing transcription to resume from the new 3’-end .

The TCEA3 gene is located on chromosome 1p36.12 in humans. It is a member of the transcription elongation factor A (SII) family, which also includes TCEA1 and TCEA2. The protein encoded by TCEA3 contains several conserved domains that are essential for its function, including the TFIIS central domain .

TCEA3 is predicted to be involved in various biological processes, including DNA-templated transcription, cell differentiation, and response to stimulus . It is predominantly located in the nucleus, where it interacts with other transcription factors and components of the transcription machinery to facilitate efficient gene expression .

Mutations or dysregulation of TCEA3 have been associated with certain diseases. For example, TCEA3 has been linked to infantile myofibromatosis, a rare condition characterized by the development of benign tumors in the skin, muscle, and bones . Understanding the role of TCEA3 in transcription elongation and its involvement in disease can provide insights into potential therapeutic targets for related conditions.

Human recombinant TCEA3 is used in various research applications to study its function and interactions with other proteins. Recombinant proteins are produced through genetic engineering techniques, allowing researchers to obtain large quantities of pure protein for experimental purposes. These studies can help elucidate the mechanisms by which TCEA3 regulates transcription elongation and its broader implications in cellular processes.