TCEAL7 Human

Transcription Elongation Factor A (SII)-Like 7, also known as TCEA3, is a protein that plays a crucial role in the process of transcription elongation. This protein is part of the transcription elongation factor family, which is essential for the proper functioning of RNA polymerase II during the transcription of DNA into RNA. The human recombinant form of this protein is produced using recombinant DNA technology, which allows for the production of large quantities of the protein for research and therapeutic purposes.

Transcription Elongation Factor A (SII)-Like 7 is characterized by its ability to interact with RNA polymerase II and facilitate the elongation phase of transcription. This protein helps to overcome transcriptional pausing and ensures the efficient synthesis of RNA. It is predicted to be involved in transcription, DNA-templated processes, and is located in the nucleus .

The primary function of Transcription Elongation Factor A (SII)-Like 7 is to assist RNA polymerase II in overcoming obstacles that may impede the transcription process. These obstacles can include DNA sequences, bound proteins, or nucleosome structures that act as barriers to the elongating RNA polymerase II complex. By interacting with RNA polymerase II, Transcription Elongation Factor A (SII)-Like 7 helps to maintain the processivity of the enzyme, allowing it to efficiently transcribe the DNA template into RNA .

The human recombinant form of Transcription Elongation Factor A (SII)-Like 7 is produced using recombinant DNA technology. This involves the insertion of the gene encoding the protein into a suitable expression vector, which is then introduced into a host organism, such as bacteria or yeast. The host organism is cultured under conditions that promote the expression of the protein, which is then purified using various biochemical techniques. This method allows for the production of large quantities of the protein, which can be used for research and therapeutic applications.

Transcription Elongation Factor A (SII)-Like 7 is an important tool in molecular biology research. It is used to study the mechanisms of transcription elongation and the regulation of gene expression. Additionally, the protein has potential therapeutic applications, particularly in the treatment of diseases that involve dysregulation of transcription. By understanding the role of Transcription Elongation Factor A (SII)-Like 7 in transcription, researchers can develop targeted therapies that modulate its activity to treat various conditions.