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Recombinant Proteins
Product List
S100P Human
S100 Calcium Binding Protein P Human Recombinant
The Recombinant Human S100P has a molecular mass of 10.4 kDa containing 95 amino acid residues of the human S100P.
Shipped with Ice Packs 
Cat. No.
BT1814
Source
Escherichia Coli.
Appearance
Filtered White lyophilized (freeze-dried) powder.
S100P Human, His
S100 Calcium Binding Protein P Human Recombinant, His Tag
S100P Human Recombinant produced in E.Coli is a single, non-glycosylated,
polypeptide chain containing 115 amino acids (1-95a.a.) and having a molecular mass of 12.6 kDa. S100P protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.
Shipped with Ice Packs
Cat. No.
BT1920
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.
S100Z Human
S100 Calcium Binding Protein Z Human Recombinant
S100Z Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids (1-99 a.a.) and having a molecular mass of 13.7kDa. The S100Z is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT2004
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.
SNTN Human
Sentan Cilia Apical Structure Protein Human Recombinant
SNTN Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 167 amino acids (1-147a.a.) and having a molecular mass of 18.6kDa.
The SNTN is purified by proprietary chromatographic techniques.
The SNTN is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT2043
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.
CAB39 Human
Calcium Binding Protein 39 Human Recombinant
CAB39 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 361 amino acids (1-341 a.a.) and having a molecular mass of 42 kDa. The CAB39 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28693
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.
CAB39L Human
Calcium Binding Protein 39 Like Human Recombinant
CAB39L Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 360 amino acids (1-337a.a) and having a molecular mass of 41.5kDa. CAB39L is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28754
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.
CABP7 Human
Calcium Binding Protein 7 Human Recombinant
CABP7 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 208 amino acids (1-188 a.a.) and having a molecular mass of 23.7kDa.
CABP7 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28811
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.
CACYBP Human
Calcyclin Binding Protein Human Recombinant
CACYBP Human Recombinant produced in E.Coli is a single, non-glycosylated,
polypeptide chain containing 205 amino acids (1-185a.a.) and having a molecular mass of 23.4 kDa. CACYBP protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.
Shipped with Ice Packs
Cat. No.
BT28907
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.
CALN1 Human
Calnueron-1 Human Recombinant
CALN1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 212 amino acids (1-192 a.a.) and having a molecular mass of 24kDa. The CALN1 is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29002
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.
CAMLG Human
Calcium Modulating Ligand Human Recombinant
CAMLG Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 212 amino acids (1-189) and having a molecular mass of 23.2kDa.
CAMLG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29081
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.
Introduction
Definition and Classification
Calcium binding proteins (CaBPs) are a diverse group of proteins that have the ability to bind calcium ions (Ca²⁺) through specific domains known as EF-hand motifs. These proteins play crucial roles in various cellular processes by regulating calcium signaling pathways. CaBPs can be classified into several families based on their structure and function, including calmodulins, troponins, S100 proteins, and annexins.
Biological Properties
Key Biological Properties:
- Calcium Binding: CaBPs have high affinity for calcium ions, which allows them to act as calcium sensors and buffers.
- Conformational Changes: Binding of calcium induces conformational changes in CaBPs, enabling them to interact with target proteins.
- Versatility: CaBPs are involved in a wide range of cellular functions due to their ability to bind calcium and interact with various proteins.
Expression Patterns:
- CaBPs are ubiquitously expressed in many tissues, but their expression levels can vary significantly depending on the tissue type and physiological conditions.
Tissue Distribution:
- Calmodulins: Found in almost all eukaryotic cells.
- Troponins: Predominantly present in cardiac and skeletal muscles.
- S100 Proteins: Expressed in the brain, heart, and other tissues.
- Annexins: Widely distributed in various tissues, including the lungs, liver, and kidneys.
Biological Functions
Primary Biological Functions:
- Signal Transduction: CaBPs play a key role in translating calcium signals into cellular responses.
- Muscle Contraction: Troponins regulate muscle contraction by controlling the interaction between actin and myosin.
- Cell Cycle Regulation: Calmodulins are involved in cell cycle progression and division.
- Neurotransmitter Release: S100 proteins modulate neurotransmitter release in the nervous system.
Role in Immune Responses:
- CaBPs are involved in the activation and regulation of immune cells, such as T cells and macrophages, by modulating calcium-dependent signaling pathways.
Pathogen Recognition:
- Certain CaBPs, like S100 proteins, can recognize and bind to pathogen-associated molecular patterns (PAMPs), playing a role in the innate immune response.
Modes of Action
Mechanisms with Other Molecules and Cells:
- CaBPs interact with a variety of target proteins, including enzymes, ion channels, and structural proteins, to modulate their activity.
Binding Partners:
- Calmodulins: Bind to and regulate kinases, phosphatases, and other signaling proteins.
- Troponins: Interact with actin and myosin in muscle fibers.
- S100 Proteins: Bind to receptors on immune cells and other target proteins.
- Annexins: Interact with phospholipids and membrane proteins.
Downstream Signaling Cascades:
- CaBPs initiate and regulate various signaling pathways, such as the calcium/calmodulin-dependent protein kinase (CaMK) pathway, which is involved in processes like memory formation and muscle contraction.
Regulatory Mechanisms
Regulatory Mechanisms that Control Expression and Activity:
- Transcriptional Regulation: The expression of CaBPs is regulated by transcription factors that respond to cellular signals and environmental cues.
- Post-Translational Modifications: CaBPs can undergo modifications such as phosphorylation, acetylation, and ubiquitination, which can alter their activity, stability, and interactions with other proteins.
Applications
Biomedical Research:
- CaBPs are used as markers to study calcium signaling pathways and their role in various diseases, including cancer and neurodegenerative disorders.
Diagnostic Tools:
- Elevated levels of certain CaBPs, such as troponins, are used as biomarkers for diagnosing myocardial infarction and other cardiac conditions.
Therapeutic Strategies:
- Targeting CaBPs and their interactions with other proteins is being explored as a potential therapeutic approach for treating diseases like cancer, heart disease, and inflammatory disorders.
Role in the Life Cycle
Role Throughout the Life Cycle:
- Development: CaBPs are essential for proper embryonic development, particularly in the formation of the nervous system and muscles.
- Aging: Changes in the expression and function of CaBPs are associated with aging and age-related diseases, such as Alzheimer’s disease and sarcopenia.
- Disease: Dysregulation of CaBPs is implicated in various diseases, including cancer, cardiovascular diseases, and neurodegenerative disorders.
