CAMLG Human

The CAMLG gene is located on chromosome 5 in humans . The protein encoded by this gene is an integral membrane protein that resides primarily in the endoplasmic reticulum . It is known to interact with cyclophilin B, a protein that binds to cyclosporin A, an immunosuppressant drug .

CAMLG is involved in the calcium signal transduction pathway. It functions similarly to cyclosporin A by binding to cyclophilin B and acting downstream of the T-cell receptor (TCR) and upstream of calcineurin . This interaction leads to an influx of calcium, which is essential for T-cell activation . CAMLG is also required for the post-translational delivery of tail-anchored proteins to the endoplasmic reticulum .

CAMLG plays a significant role in the immune system. It is essential for the survival of peripheral follicular B cells . The protein is involved in the elevation of intracellular calcium levels, which is crucial for T-cell signaling . Additionally, CAMLG has been shown to interact with the TNF receptor TACI, further implicating its role in immune responses .

Mutations or dysregulation of the CAMLG gene can lead to various disorders. For instance, CAMLG is associated with congenital disorders of glycosylation, type Iiz, and melanoacanthoma . Understanding the function and mechanism of CAMLG can provide insights into potential therapeutic targets for immune-related diseases.

Research on CAMLG has provided valuable insights into its role in calcium signaling and immune responses. The recombinant form of this protein is used in various studies to understand its function and potential therapeutic applications. The ability to modulate calcium signaling pathways makes CAMLG a promising target for drug development, particularly in the context of immunosuppressive therapies.