CAB39 Human
Calcium Binding Protein 39 Human Recombinant
Cat. No.
BT28693
Source
Escherichia Coli.
Synonyms
MO25, CAB-39, CGI-66, FLJ22682, Calcium Binding Protein 39.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
CAB39 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 361 amino acids (1-341 a.a.) and having a molecular mass of 42 kDa. The CAB39 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Product Specs
Introduction
CAB39 protein works with STE20-related adaptor-alpha pseudo kinase to form a regulatory complex. This complex can stimulate the activity of the LKB1 tumor suppressor protein kinase. CAB39 acts as a scaffolding component of the STK11/STRAD complex, which regulates STK11 activity and where it is located in the cell.
Description
CAB39 Recombinant Human protein is produced in E. coli. It is a single polypeptide chain that does not contain glycosylation. It contains 361 amino acids (specifically amino acids 1 through 341) and has a molecular mass of 42 kDa. The CAB39 is fused to a 20 amino acid His-Tag at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear and colorless solution that is sterile and has been filtered.
Formulation
The CAB39 solution (0.5mg/ml) contains 20mM Tris-HCl with a pH of 8, 1mM DTT, and 10% glycerol.
Stability
If the entire vial will be used within 2-4 weeks, store at 4 degrees Celsius. For longer periods of time, store frozen at -20 degrees Celsius. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity
Purity is greater than 90.0% as determined by SDS-PAGE.
Synonyms
MO25, CAB-39, CGI-66, FLJ22682, Calcium Binding Protein 39.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM KEILYGTNEK EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ IFNNILRRQI GTRTPTVEYI CTQQNILFML LKGYESPEIA LNCGIMLREC IRHEPLAKII LWSEQFYDFF RYVEMSTFDI ASDAFATFKD LLTRHKLLSA EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR HNFTIMTKYISKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A.
Product Science Overview
Structure and Function
CAB39 is a protein coding gene that produces a protein involved in kinase binding activity and protein serine/threonine kinase activator activity . The protein is composed of 361 amino acids and has a molecular mass of approximately 42 kilodaltons . It is a single, non-glycosylated polypeptide chain .
CAB39 forms a regulatory complex with the STE20-related adaptor-alpha pseudo kinase. This complex is capable of stimulating the activity of the LKB1 tumor suppressor protein kinase, which is essential for various cellular functions, including cell polarity, metabolism, and growth .
Biological Role
CAB39 is involved in several critical biological processes:
- Intracellular Signal Transduction: It plays a role in transmitting signals within cells, which is vital for cellular responses to external stimuli .
- Peptidyl-Serine Phosphorylation: CAB39 is involved in the phosphorylation of serine residues in proteins, a key step in many signaling pathways .
- Positive Regulation of Protein Phosphorylation: It enhances the phosphorylation of proteins, which can activate or deactivate various cellular functions .
Clinical Significance
CAB39 has been implicated in several diseases, including:
- Hepatocellular Carcinoma: It is considered a biomarker for this type of liver cancer .
- Pancreatic Cancer: CAB39 is also a biomarker for pancreatic cancer .
- Colon Signet Ring Adenocarcinoma: This is another type of cancer associated with CAB39 .
- Myopathy, Myofibrillar, 1: A muscle disorder linked to mutations in the CAB39 gene .
Localization
Recombinant Production
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
