CAB39L Human

The CAB39L gene is located on chromosome 13 and encodes a protein that consists of 341 amino acids with a molecular mass of approximately 42 kDa . The recombinant form of this protein is typically produced in E. coli and includes a 20 amino acid His-Tag at the N-terminus to facilitate purification .

CAB39L is involved in several key biological pathways:

• Signal Transduction: It acts as a component of a complex that binds and activates the serine/threonine kinase STK11/LKB1. This complex is essential for stabilizing the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 .
• Kinase Activation: CAB39L enables protein serine/threonine kinase activator activity, which is crucial for intracellular signal transduction and the regulation of various cellular processes .

CAB39L is expressed in various tissues, with significant roles in the innate immune system and endochondral ossification pathways . It is also implicated in diseases such as monocytic leukemia and immunodeficiency 10 .

Mutations or dysregulation of the CAB39L gene have been associated with several diseases, including monocytic leukemia and immunodeficiency 10 . As a biomarker, it holds potential for diagnostic and therapeutic applications in these conditions.

The recombinant form of CAB39L is produced using E. coli expression systems. The protein is purified using chromatographic techniques to ensure high purity and functionality . This recombinant protein is valuable for research purposes, including studies on protein-protein interactions, kinase activation, and signal transduction pathways.