Recombinant Proteins
Product List
RHOA Human
Ras Homolog Gene Family Member A Human Recombinant
The RHOA is purified by proprietary chromatographic techniques.
RHOB Human
Ras Homolog Gene Family Member B Human Recombinant
RHOB is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RHOC Human
Ras Homolog Gene Family Member C Human Recombinant
RHOD Human
Ras Homolog Gene Family Member D Human Recombinant
RHOD produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (18-207 a.a.) and having a molecular mass of 23.8kDa.
RHOD is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RHOG Human
Ras Homolog Gene Family Member G Human Recombinant
RHOG is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RHOQ Human
Ras Homolog Gene Family Member Q Human Recombinant
RHOQ is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RHOV Human
Ras Homolog Gene Family Member V Human Recombinant
RHOV is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
The RAS oncogene family is a group of genes that encode small GTPases, which are involved in transmitting signals within cells. These proteins act as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state. The RAS family is divided into three main members: KRAS, HRAS, and NRAS . Each of these genes plays a crucial role in cell growth, differentiation, and survival.
Key Biological Properties: RAS proteins are small GTPases that function as binary molecular switches. They are involved in various cellular processes, including cell proliferation, differentiation, and survival .
Expression Patterns: RAS proteins are ubiquitously expressed in all animal cell lineages and organs .
Tissue Distribution: These proteins are found in various tissues, including the brain, liver, pancreas, and skin .
Primary Biological Functions: RAS proteins play a pivotal role in regulating cell proliferation, differentiation, and survival. They are involved in transmitting signals from cell surface receptors to the nucleus .
Role in Immune Responses and Pathogen Recognition: RAS proteins are involved in the immune response by regulating the activation and proliferation of immune cells. They also play a role in pathogen recognition by modulating signaling pathways that respond to infections .
Mechanisms with Other Molecules and Cells: RAS proteins interact with various molecules and cells through their GTPase activity. They bind to guanine nucleotides (GTP and GDP) and cycle between active and inactive states .
Binding Partners: RAS proteins interact with a variety of binding partners, including guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), which regulate their activity .
Downstream Signaling Cascades: Upon activation, RAS proteins initiate a cascade of downstream signaling events that lead to the activation of various effector proteins, including RAF kinases, PI3K, and RalGDS .
Transcriptional Regulation: The expression of RAS genes is regulated at the transcriptional level by various transcription factors and signaling pathways .
Post-Translational Modifications: RAS proteins undergo several post-translational modifications, including farnesylation, palmitoylation, and phosphorylation, which are essential for their proper localization and function .
Biomedical Research: RAS proteins are extensively studied in biomedical research due to their critical role in cancer development and progression .
Diagnostic Tools: Mutations in RAS genes are used as biomarkers for the diagnosis and prognosis of various cancers .
Therapeutic Strategies: Targeting RAS signaling pathways is a promising therapeutic strategy for treating RAS-driven cancers. Several inhibitors targeting RAS proteins and their downstream effectors are currently under development .
Development: RAS proteins are essential for normal development, as they regulate cell proliferation and differentiation during embryogenesis .
Aging: The activity of RAS proteins is implicated in the aging process, as dysregulated RAS signaling can lead to cellular senescence and age-related diseases .
Disease: Mutations in RAS genes are associated with various diseases, including cancer, developmental disorders, and neurodegenerative diseases .
