Recombinant Proteins
Product List
CST3 Rat
Cystatin C Rat Recombinant
CST3 Rat, sf9
Cystatin C Rat Recombinant, sf9
CST4 Human
Cystatin 4 Human Recombinant
CST4 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CST4 Human, sf9
Cystatin 4 Human Recombinant, sf9
CST5 Human
Cystatin 5 Human Recombinant
CST5 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 123 amino acids (26-142 a.a) and having a molecular mass of 14.36kDa. CST5 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
CST6 Human
Cystatin E/M Human Recombinant
The CST6 is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
CST6 Human, Active
Cystatin E/M, BioActive Human Recombinant
CST6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 142 amino acids (29-149 a.a.) and having a molecular mass of 15.9kDa.
CST6 is fused to a 21 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.
CST7 Human
Cystatin 7 Human Recombinant
CST7 is fused to a 7 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
CST9 Human
Cystatin 9 Human Recombinant
CST9 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CSTA Human, Active
Cystatin-A Human Recombinant, Active
The Cystatin A is fused to a 20 amino acid His tag at N-terminus and purified by proprietary chromatographic techniques.
Introduction
Cystatins are a family of cysteine protease inhibitors that play a crucial role in regulating proteolytic activity within cells. They are classified into three main types:
- Type 1 Cystatins (Stefins): These are primarily intracellular proteins found in the cytosol of various cell types .
- Type 2 Cystatins: These are mainly extracellular secreted polypeptides, found in most body fluids .
- Type 3 Cystatins (Kininogens): These are multidomain proteins, with mammalian representatives including high-molecular-mass and low-molecular-mass kininogens .
Cystatins exhibit several key biological properties:
- Inhibitory Activity: They inhibit cysteine proteases such as cathepsins and legumain, which are involved in protein degradation .
- Expression Patterns: Cystatins are expressed in a wide variety of tissues and body fluids .
- Tissue Distribution: They are found in virtually all tissues, with specific types being more prevalent in certain tissues. For example, cystatin C is found in high concentrations in the brain and kidneys .
Cystatins serve several primary biological functions:
- Regulation of Protease Activity: They regulate the activity of cysteine proteases, preventing excessive proteolysis .
- Immune Response: Cystatins modulate immune responses by influencing the activity of cathepsins involved in antigen presentation and cytokine production .
- Pathogen Recognition: They play a role in recognizing and responding to pathogens by inhibiting proteases that pathogens use to invade host tissues .
Cystatins interact with other molecules and cells through several mechanisms:
The expression and activity of cystatins are controlled by various regulatory mechanisms:
Cystatins have several applications in biomedical research and clinical practice:
Cystatins play a role throughout the life cycle, from development to aging and disease:
- Development: They are involved in regulating protease activity during embryonic development and tissue remodeling .
- Aging: Changes in cystatin levels and activity have been associated with aging and age-related diseases .
- Disease: Dysregulation of cystatin activity is implicated in various diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer .
