Recombinant Proteins
Product List
PhI p 12
Pollen Allergen Phl p 12 Recombinant
Recombinant PhI p 12 produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 15,607 Dalton.
PhI p 12 is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.
PhI p 2
Pollen allergen Phl p 2 Recombinant
PhI p 2 is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.
PhI p 5
Group V allergen Phl p 5.0203 Recombinant
PhI p 5 is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.
PhI p 6
Pollen allergen Phl p 6 Recombinant
PhI p 6 is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.
Phospholipase A2
Phospholipase A2 P00630 Bee Venom Protein Recombinant
The E.Coli derived recombinant protein contains phospholipase P00630 bee venom protein epitopes, 26-162 amino acids. Phospholipase A2 P00630 Bee Venom is fused to a 6xHis tag at C-terminus
Polcalcin Phl p 7
Pollen Allergen Phl p 7 Recombinant
Recombinant Polcalcin Phl p 7 produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 9.0 kDa. Polcalcin Phl p 7 is purified by proprietary chromatographic techniques.
Soybean P34
Soybean P34 Protein Recombinant
Soybean P34 GST
Soybean P34 Protein Recombinant, GST Tag
Tri a 14.0101
Non-Specific Lipid-Transfer Protein Tri a 14 Recombinant
Recombinant Non-Specific Lipid-Transfer Protein Tri a 14 produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 13kDa.
Tri a 14.0101 is expressed with a 6xHis tag and purified by proprietary chromatographic techniques.
Aln G 1.0101
Major pollen allergen Aln g 1 Recombinant
Aln G 1.0101 is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.
Introduction
Allergy is an immune system response to a foreign substance (allergen) that is not typically harmful to the body. These foreign substances can include pollen, pet dander, certain foods, and insect stings. Allergies are classified into several types based on the mechanism of the immune response:
- Type I (Immediate Hypersensitivity): Mediated by IgE antibodies, leading to reactions such as hay fever, asthma, and anaphylaxis.
- Type II (Cytotoxic Hypersensitivity): Involves IgG or IgM antibodies targeting cells, leading to conditions like hemolytic anemia.
- Type III (Immune Complex Hypersensitivity): Involves immune complexes that deposit in tissues, causing conditions like systemic lupus erythematosus.
- Type IV (Delayed-Type Hypersensitivity): Mediated by T cells, leading to reactions such as contact dermatitis and tuberculin reactions.
- Key Biological Properties: Allergies involve the immune system’s overreaction to harmless substances. Key players include IgE antibodies, mast cells, basophils, and various cytokines.
- Expression Patterns: IgE antibodies are produced by B cells and are specific to particular allergens. Mast cells and basophils express high-affinity IgE receptors (FcεRI).
- Tissue Distribution: Mast cells are found in connective tissues, particularly near blood vessels and nerves, while basophils circulate in the blood.
- Primary Biological Functions: The primary function of the allergic response is to protect the body from perceived threats. This involves the release of histamines and other mediators that cause inflammation and other symptoms.
- Role in Immune Responses: Allergies play a role in immune responses by activating various immune cells and mediators.
- Pathogen Recognition: Although allergies are typically responses to non-pathogenic substances, the mechanisms involved are similar to those used in pathogen recognition.
- Mechanisms with Other Molecules and Cells: Allergens bind to IgE antibodies on the surface of mast cells and basophils, leading to cell activation and degranulation.
- Binding Partners: Key binding partners include IgE antibodies, FcεRI receptors, and allergens.
- Downstream Signaling Cascades: Activation of mast cells and basophils leads to the release of histamines, leukotrienes, and other inflammatory mediators, triggering symptoms like itching, swelling, and bronchoconstriction.
- Regulatory Mechanisms: The expression and activity of IgE and other molecules involved in allergic responses are tightly regulated by various factors.
- Transcriptional Regulation: Genes encoding IgE and FcεRI are regulated by transcription factors such as NF-κB.
- Post-Translational Modifications: Post-translational modifications, such as phosphorylation, play a role in the activation and function of immune cells involved in allergies.
- Biomedical Research: Understanding allergies helps in developing treatments and preventive measures.
- Diagnostic Tools: Skin prick tests, blood tests for specific IgE, and challenge tests are used to diagnose allergies.
- Therapeutic Strategies: Treatments include antihistamines, corticosteroids, and immunotherapy (allergy shots).
- Throughout the Life Cycle: Allergies can develop at any age and may change over time. They can affect quality of life and may be associated with other conditions such as asthma and eczema.
- From Development to Aging and Disease: Allergies can impact various stages of life, from childhood to old age, and may influence the development of other immune-related diseases.
