Polcalcin Phl p 7

Phl p 7 is a minor allergen derived from the pollen of timothy grass (Phleum pratense). It belongs to the polcalcin family of pollen panallergens, which are known for their calcium-binding properties . This allergen is significant due to its role in causing allergic reactions in sensitive individuals.

Phl p 7 is a non-glycosylated protein that contains two EF-hand calcium-binding motifs . These motifs are crucial for the protein’s ability to bind calcium ions, which in turn affects its structural stability and allergenic properties. The protein is highly cross-reactive, meaning it can trigger allergic reactions in individuals sensitized to other pollen allergens .

Recombinant Phl p 7 is a laboratory-produced version of the natural allergen. It is created using gene engineering techniques to produce a protein that is identical or very similar to the natural allergen. This recombinant form is used in various diagnostic and therapeutic applications, including allergy testing and immunotherapy .

Recombinant Phl p 7 is used in allergy diagnostics to identify specific IgE antibodies in patients’ blood serum. This helps in accurately diagnosing allergies to timothy grass pollen and other related allergens . Additionally, recombinant Phl p 7 is being explored as a potential candidate for allergen-specific immunotherapy (AIT). AIT aims to desensitize patients to specific allergens, thereby reducing the severity of allergic reactions .

Research on Phl p 7 has revealed its potential as a diagnostic marker and vaccine candidate for immunotherapy . Studies have shown that Phl p 7 contains multiple IgE-binding epitopes, making it a valuable target for developing hypoallergenic variants for safer and more effective immunotherapy .