Recombinant Proteins
Product List
UBLCP1 Human
Ubiquitin-Like Domain Containing CTD Phosphatase 1 Human Recombinant
UBLCP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
UBQLN2 Human
Ubiquilin 2 Human Recombinant
UFM1 Human
Ubiquitin-Fold Modifier 1 Human Recombinant
URM1 Human
Ubiquitin Related Modifier 1 Human Recombinant
URM1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
USP14 Human
Ubiquitin Specific Peptidase 14 Human Recombinant
USP15 Human
Ubiquitin Specific Peptidase 15 Human Recombinant
USP46 Human
Ubiquitin Specific Peptidase 46 Human Recombinant
SUMO2 Human
Small Ubiquitin-Related Modifier 2 Human Recombinant
The SUMO-2 is purified by proprietary chromatographic techniques.
SUMO3 Human
Small Ubiquitin-Related Modifier 3 Human Recombinant
SUMO3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
UBD Human
Ubiquitin-D Human Recombinant
UBD Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 188 amino acids (1-165 a.a.) and having a molecular mass of 20.9kDa.
UBD is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Ubiquitin is a small regulatory protein, approximately 8.6 kDa in size, found ubiquitously in eukaryotic cells . It consists of 76 amino acids and is highly conserved across species . Ubiquitin is encoded by four genes in the human genome: UBB, UBC, UBA52, and RPS27A . The primary function of ubiquitin is to tag proteins for degradation via the proteasome, a process known as ubiquitination .
Key Biological Properties: Ubiquitin is a globular protein that is highly stable and resistant to denaturation . It can withstand a wide range of pH and temperatures .
Expression Patterns: Ubiquitin is expressed in all eukaryotic cells and is involved in various cellular processes .
Tissue Distribution: Ubiquitin is found in the cell-surface membrane, cytoplasm, and nucleus of eukaryotic cells .
Primary Biological Functions: The main function of ubiquitin is to label improperly folded, unwanted, or damaged proteins for proteasomal degradation . It also plays a role in altering the cellular location, structural conformation, or biological function of target proteins .
Role in Immune Responses and Pathogen Recognition: Ubiquitin is involved in the regulation of immune responses and pathogen recognition by modulating the activity of immune-related proteins .
Ubiquitin exerts its effects through a process called ubiquitination, which involves three main steps: activation, conjugation, and ligation . These steps are performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively . Ubiquitin can mark proteins for degradation, alter their cellular location, affect their activity, and promote or prevent protein interactions .
Transcriptional Regulation: The expression of ubiquitin is tightly regulated at the transcriptional level to ensure proper cellular function .
Post-Translational Modifications: Ubiquitin itself can undergo various post-translational modifications, such as phosphorylation, which can affect its function and interactions with other proteins .
Biomedical Research: Ubiquitin is widely used in biomedical research to study protein degradation, signal transduction, and other cellular processes .
Diagnostic Tools: Ubiquitin-based assays are used to detect and quantify protein ubiquitination in various diseases .
Therapeutic Strategies: Targeting the ubiquitin-proteasome system has been explored as a therapeutic strategy for treating cancer and other diseases .
Ubiquitin plays a crucial role throughout the life cycle, from development to aging and disease . During cell growth and proliferation, ubiquitin-mediated degradation is essential for maintaining genome integrity and ensuring proper cell cycle progression . Dysregulation of ubiquitin pathways can lead to various diseases, including cancer .
