Recombinant Proteins
Product List
CSTA Human, His
Cystatin A Human Recombinant, His tag
CSTA is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CSTB Human
Cystatin B Human Recombinant
CSTB Human Recombinant fused to a 20 a.a His-Tag at N-Terminus produced in E.Coli is a single, non-glycosylated polypeptide chain containing 118 amino acids (1-98 a.a) and having a molecular mass of 13 kDa.
CSTB Human, Active
Cystatin-B, BioActive Human Recombinant
CSTB Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 118 amino acids (1-98 a.a.) and having a molecular mass of 13kDa.
CSTB is fused to a 20 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.
Cystatin-C Protein
Cystatin-C Human Recombinant
Cystatin-C Human Recombinant produced in E.Coli is a single, non- glycosylated polypeptide chain containing 120 amino acids and having a molecular mass of 13.3kDa.
Cystatin-C is purified by proprietary chromatographic techniques.
Escherichia Coli.
Introduction
Cystatins are a family of cysteine protease inhibitors that play a crucial role in regulating proteolytic activity within cells. They are classified into three main types:
- Type 1 Cystatins (Stefins): These are primarily intracellular proteins found in the cytosol of various cell types .
- Type 2 Cystatins: These are mainly extracellular secreted polypeptides, found in most body fluids .
- Type 3 Cystatins (Kininogens): These are multidomain proteins, with mammalian representatives including high-molecular-mass and low-molecular-mass kininogens .
Cystatins exhibit several key biological properties:
- Inhibitory Activity: They inhibit cysteine proteases such as cathepsins and legumain, which are involved in protein degradation .
- Expression Patterns: Cystatins are expressed in a wide variety of tissues and body fluids .
- Tissue Distribution: They are found in virtually all tissues, with specific types being more prevalent in certain tissues. For example, cystatin C is found in high concentrations in the brain and kidneys .
Cystatins serve several primary biological functions:
- Regulation of Protease Activity: They regulate the activity of cysteine proteases, preventing excessive proteolysis .
- Immune Response: Cystatins modulate immune responses by influencing the activity of cathepsins involved in antigen presentation and cytokine production .
- Pathogen Recognition: They play a role in recognizing and responding to pathogens by inhibiting proteases that pathogens use to invade host tissues .
Cystatins interact with other molecules and cells through several mechanisms:
The expression and activity of cystatins are controlled by various regulatory mechanisms:
Cystatins have several applications in biomedical research and clinical practice:
Cystatins play a role throughout the life cycle, from development to aging and disease:
- Development: They are involved in regulating protease activity during embryonic development and tissue remodeling .
- Aging: Changes in cystatin levels and activity have been associated with aging and age-related diseases .
- Disease: Dysregulation of cystatin activity is implicated in various diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer .
