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Product List
PPM1F Human
Protein Phosphatase 1F Human Recombinant
PPM1F Human Recombinant produced in E. coli is a single polypeptide
chain containing 477 amino acids (1-454) and having a molecular mass of
52kDa.
PPM1F is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs 
PPM1G Human
Protein Phosphatase 1G Human Recombinant
PPM1G Human Recombinant fused with His-tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 250 amino acids and having a molecular mass of 27 kDa.
The PPM1G is purified by proprietary chromatographic techniques.
The PPM1G is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT104
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.
PPM1G Human, 546 a.a.
Protein Phosphatase 1G 546 a.a. Human Recombinant
PPM1G Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 566 amino acids (1-546) and having a molecular mass of 61.4 kDa.
The PPM1G is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
The PPM1G is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Shipped with Ice Packs
PPP1CA Human
Protein Phosphatase 1, Catalytic Subunit Alpha Human Recombinant
PPP1CA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 350 amino acids (1-330 a.a) and having a molecular mass of 39.7kDa.
PPP1CA is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
PPP1CA is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT253
Source
Escherichia Coli.
Appearance
Sterile filtered yellowish solution.
PPP1CC Human
Protein Phosphatase 1, Catalytic Subunit Gamma Human Recombinant
PPP1CC Human Recombinant produced in E. coli is a single polypeptide chain containing 343 amino acids (1-323) and having a molecular mass of 39.1kDa.
PPP1CC is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
PPP1CC is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
PPP1CC Human, Active
Protein Phosphatase 1, Catalytic Subunit Gamma Human Recombinant, Active
PPP1CC produced in E.Coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (1-323a.a.) and having a molecular mass of 39.1kDa.
PPP1CC is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
PPP1R14A Human
Protein Phosphatase-1 Regulatory Subunit-14A Human Recombinant
Recombinant PPP1R14A produced in E.Coli is a single, non-glycosylated polypeptide chain containing 167 amino acids and having a molecular mass of 18kDa. PPP1R14A is fused to a 20 aa His Tag and is purified by conventional chromatography techniques.
Shipped with Ice Packs
Cat. No.
BT437
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.
PPP1R1A Human
Protein Phosphatase Inhibitor-1 Human Recombinant
PPP1R1A Human Recombinant fused with His tag at C-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 179 amino acids and having a molecular mass of 20 kDa.
The PPP1R1A is purified by proprietary chromatographic techniques.
The PPP1R1A is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT547
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.
PPP1R2 Human
Protein Phosphatase 1, Regulatory Subunit 2 Human Recombinant
PPP1R2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 189 amino acids (1-166 a.a) and having a molecular mass of 21kDa.
PPP1R2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
PPP1R2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT635
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution.
PPP1R8 Human
Protein Phosphatase 1, Regulatory Subunit 8 Human Recombinant
PPP1R8 Human Recombinant produced in E. coli is a single polypeptide chain containing 359 amino acids (1-351) and having a molecular mass of 39.5 kDa.
PPP1R8 is fused to a 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
PPP1R8 is fused to a 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Introduction
Definition and Classification
Phosphatases are a group of enzymes that catalyze the removal of phosphate groups from molecules, a process known as dephosphorylation. They play a crucial role in various cellular processes by regulating the phosphorylation state of proteins and other molecules. Phosphatases are broadly classified into two main categories:
- Protein Phosphatases: These enzymes specifically target phosphorylated amino acid residues in proteins. They are further divided into:
- Serine/Threonine Phosphatases: Target serine or threonine residues.
- Tyrosine Phosphatases: Target tyrosine residues.
- Dual-Specificity Phosphatases: Can target both serine/threonine and tyrosine residues.
- Non-Protein Phosphatases: These enzymes act on non-protein substrates, such as nucleotides, sugars, and lipids.
Biological Properties
Key Biological Properties:
- Catalytic Activity: Phosphatases hydrolyze phosphate esters, releasing inorganic phosphate.
- Substrate Specificity: They exhibit specificity for their substrates, which can be proteins, nucleotides, or other molecules.
Expression Patterns:
- Phosphatases are ubiquitously expressed in various tissues and cell types, with specific isoforms showing distinct expression patterns.
Tissue Distribution:
- Protein Phosphatases: Widely distributed across tissues, with high expression in the brain, liver, and muscles.
- Non-Protein Phosphatases: Found in various tissues, depending on their specific substrates.
Biological Functions
Primary Biological Functions:
- Regulation of Signal Transduction: Phosphatases modulate signaling pathways by dephosphorylating key signaling molecules.
- Cell Cycle Control: They play a role in cell cycle progression by regulating the phosphorylation state of cell cycle proteins.
- Metabolic Regulation: Phosphatases are involved in metabolic pathways by dephosphorylating metabolic enzymes.
Role in Immune Responses:
- Phosphatases regulate immune cell activation and function by modulating signaling pathways involved in immune responses.
Pathogen Recognition:
- Some phosphatases are involved in recognizing and responding to pathogen-associated molecular patterns (PAMPs), contributing to the immune defense.
Modes of Action
Mechanisms with Other Molecules and Cells:
- Phosphatases interact with various molecules, including proteins, lipids, and nucleotides, to exert their dephosphorylation activity.
Binding Partners:
- They often form complexes with other proteins, which can regulate their activity and substrate specificity.
Downstream Signaling Cascades:
- By dephosphorylating key signaling molecules, phosphatases influence downstream signaling pathways, affecting cellular responses such as proliferation, differentiation, and apoptosis.
Regulatory Mechanisms
Regulatory Mechanisms:
- Transcriptional Regulation: The expression of phosphatases is regulated at the transcriptional level by various transcription factors and signaling pathways.
- Post-Translational Modifications: Phosphatases themselves can be regulated by post-translational modifications, such as phosphorylation, ubiquitination, and methylation, which can alter their activity, stability, and localization.
Applications
Biomedical Research:
- Phosphatases are studied to understand their role in various diseases, including cancer, diabetes, and neurodegenerative disorders.
Diagnostic Tools:
- Phosphatase activity assays are used in diagnostic tests to measure enzyme activity in biological samples, aiding in the diagnosis of certain diseases.
Therapeutic Strategies:
- Inhibitors of specific phosphatases are being developed as potential therapeutic agents for diseases where phosphatase activity is dysregulated.
Role in the Life Cycle
Role Throughout the Life Cycle:
- Development: Phosphatases are involved in embryonic development by regulating signaling pathways that control cell differentiation and tissue formation.
- Aging: Changes in phosphatase activity have been associated with aging and age-related diseases, such as Alzheimer’s disease.
- Disease: Dysregulation of phosphatase activity is implicated in various diseases, including cancer, where altered phosphorylation states can lead to uncontrolled cell growth and proliferation.
