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Cytokines
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Product List
CCNA2 Human
Cyclin-A2 Human Recombinant
CCNA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 456 amino acids (1-432 a.a) and having a molecular mass of 51.1kDa.
CCNA2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CCNA2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs 
Cat. No.
BT2050
Source
Escherichia Coli.
Appearance
Sterile Filtered clear colorless solution.
CCNB1 Human
Cyclin-B1 Human Recombinant
CCNB1 Human Recombinant produced in E. coli is a single polypeptide chain containing 457 amino acids (1-433) and having a molecular mass of 50.9 kDa.
CCNB1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CCNB1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
CCNB2 Human
Cyclin-B2 Human Recombinant
CCNB2 Human Recombinant produced in E. coli is a single polypeptide chain containing 422 amino acids (1-398) and having a molecular mass of 47.9 kDa.
CCNB2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CCNB2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
CCND2 Human
Cyclin D2 Human Recombinant
CCND2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 313 amino acids (1-289 a.a.) and having a molecular mass of 35.6kDa.
CCND2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CCND2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT2274
Source
Escherichia Coli.
Appearance
Sterile Filtered clear colorless solution.
CCNG1 Human
Cyclin G1 Human Recombinant
CCNG1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 315 amino acids (1-295 a.a.) and having a molecular mass of 36.2kDa.
CCNG1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CCNG1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT2368
Source
Escherichia Coli.
Appearance
Sterile Filtered clear colorless solution.
CCNH Human
Cyclin-H Human Recombinant
CCNH Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 343 amino acids (1-323 a.a.) and having a molecular mass of 39.8 kDa. The CCNH is fused to a 20 amino acid His Tag and purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT2457
Source
Escherichia Coli.
Appearance
Sterile Filtered clear colorless solution.
CCNI Human
Cyclin-I Human Recombinant
CCNI Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 400 amino acids (1-377 a.a) and having a molecular mass of 44.9kDa.
CCNI is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CCNI is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT2555
Source
Escherichia Coli.
Appearance
Sterile Filtered clear colorless solution.
Introduction
Definition and Classification
Cyclins are a family of proteins that play a crucial role in regulating the cell cycle by activating cyclin-dependent kinases (CDKs). They were first discovered by R. Timothy Hunt in 1982 while studying the cell cycle of sea urchins . Cyclins are classified based on their behavior and function during different phases of the cell cycle. The main classes include:
- G1 Cyclins: Present during the G1 phase, they help prepare the cell for DNA replication.
- G1/S Cyclins: These cyclins appear at the transition from G1 to S phase and initiate DNA replication.
- S Cyclins: Active during the S phase, they are involved in DNA synthesis.
- M Cyclins: Present during mitosis, they help in the formation of the mitotic spindle and chromosome alignment .
Biological Properties
Cyclins exhibit distinct biological properties, including:
- Expression Patterns: Cyclin levels oscillate throughout the cell cycle, with specific cyclins peaking at different phases .
- Tissue Distribution: Cyclins are ubiquitously expressed in proliferating cells across various tissues. However, their expression levels can vary depending on the tissue type and the cell’s proliferative state .
Biological Functions
Cyclins primarily function by binding to and activating CDKs, which then phosphorylate target proteins to drive cell cycle progression . They play a role in:
- Cell Cycle Regulation: Cyclins ensure the accurate transmission of genetic information by regulating the cell cycle checkpoints .
- Immune Responses and Pathogen Recognition: Cyclins are involved in the regulation of immune cell proliferation and differentiation, which is crucial for effective immune responses .
Modes of Action
Cyclins exert their effects through several mechanisms:
Regulatory Mechanisms
The expression and activity of cyclins are tightly regulated through:
- Transcriptional Regulation: Cyclin gene expression is controlled by various transcription factors and signaling pathways .
- Post-Translational Modifications: Cyclins undergo ubiquitination and subsequent degradation by the proteasome, ensuring their levels are appropriately regulated throughout the cell cycle .
Applications
Cyclins have several applications in biomedical research and clinical settings:
Role in the Life Cycle
