Enzymes
Product List
CTSA Mouse
Cathepsin-A Mouse Recombinant
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CTSA produced in Sf9 Insect
cells is a single, glycosylated polypeptide chain containing 459 amino acids
(24-474 a.a.) and having a molecular mass of 52.4kDa (Molecular size on SDS-PAGE
will appear at approximately 50-70kDa). CTSA is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques. |
CTSB Mouse
Cathepsin-B Mouse Recombinant
CTSB Mouse, Active
Cathepsin-B Mouse Recombinant, Active
CTSC Mouse
Cathepsin-C Mouse Recombinant
CTSC Mouse Recombinant produced in HEK293 cells is a single, polypeptide chain containing 444 amino acids (25-462 a.a.) and having a molecular mass of 50.5kDa. CTSC is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
CTSD Human
Cathepsin-D Human Recombinant
CTSD produced in HEK293 cells is a single, glycosylated polypeptide chain containing 398 amino acids (21-412 a.a.) and having a molecular mass of 43.4kDa. CTSD is expressed with an 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
CTSD Mouse
Cathepsin-D Mouse Recombinant
CTSE Human
Cathepsin-E Human Recombinant
CTSF Human
Cathepsin-F Human Recombinant
CTSF Human, Sf9
Cathepsin-F Human Recombinant, Sf9
CTSF produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 474 amino acids (20-484.a.a) and having a molecular mass of 52.5kDa.
CTSF is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
Sterile filtered colorless solution.
CTSL Human
Cathepsin-L Human Recombinant
Introduction
Cathepsins are a family of proteases (enzymes that degrade proteins) found in all animals and other organisms. The term “cathepsin” is derived from the Greek words “kata-” meaning “down” and “hepsein” meaning "boil" . These enzymes are primarily located in lysosomes, where they play a crucial role in protein degradation. Cathepsins are classified into three main types based on their catalytic mechanisms: cysteine proteases, aspartic proteases, and serine proteases .
Cathepsins are involved in several primary biological functions:
The expression and activity of cathepsins are tightly regulated through several mechanisms:
- Transcriptional Regulation: Gene expression of cathepsins is controlled by transcription factors.
- Post-Translational Modifications: Cathepsins undergo modifications such as glycosylation, which affect their stability and activity .
- Endogenous Inhibitors: Proteins like stefins, cystatins, and serpins regulate cathepsin activity by inhibiting their proteolytic functions .
Cathepsins have significant applications in biomedical research, diagnostics, and therapeutics:
- Biomedical Research: They are studied for their roles in various diseases, including cancer and cardiovascular diseases .
- Diagnostic Tools: Differential expression of cathepsins can serve as biomarkers for disease progression .
- Therapeutic Strategies: Selective inhibitors of cathepsins are being developed as potential treatments for diseases .
Cathepsins play vital roles throughout the life cycle, from development to aging and disease:
- Development: They are involved in tissue remodeling during embryogenesis and development .
- Aging: Cathepsin activity is linked to the degradation of cellular components, which is crucial for maintaining cellular homeostasis .
- Disease: Dysregulated cathepsin activity is associated with various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases .
