Enzymes
Product List
ACE2 (18-615) Human
Angiotensin Converting Enzyme 2 (18-615 a.a.), Human Recombinant
The CHO derived ACE2 Human recombinant protein contains the extracellular domain amino acids 18- 615 fused to Fc tag at C-terminal and has a molecular weight of ~130 kDa. ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.
ACE2 (18-740) Human
Angiotensin Converting Enzyme 2 (18-740 a.a.), Human Recombinant
The HEK293 derived ACE2 Human recombinant protein contains the amino acids 18-740 fused to IgG-His tag ( 242 a.a. ) at N-terminal having a total Mw of 110.8 kDa. ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.
ACE2 (18-740) Human, Biotin
Angiotensin Converting Enzyme 2 (18-740 a.a.), Biotinylated Human Recombinant
The HEK293 derived ACE2 Human recombinant biotinylated protein contains the amino acids Gln 18-Ser 740 fused to His-AVI tag at C-terminal having a predicted Mw of 87.2 kDa ( migrates 95-125 kDa under reducing conditions on sds-page due to glycosilation). ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.
ACE2 (18-740) Human, Fc
Angiotensin Converting Enzyme 2 (18-740 a.a.), Fc Human Recombinant
The HEK293 derived ACE2 Human recombinant protein contains the amino acids 18-740 fused to Fc tag at C-terminal. ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.
ACE2 (19-740) Human
Angiotensin Converting Enzyme 2 (19-740 a.a.), Human Recombinant
The CHO derived ACE2 Human recombinant protein contains the extracellular domain amino acids 19-740 fused to Fc tag at C-terminal. ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.
ACE2 Mouse
Angiotensin Converting Enzyme 2 Mouse Recombinant
ACE2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 731 amino acids (18-740 aa) and having a molecular mass of 84.5kDa. ACE2 is fused to a 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
ACE2 Rat
Angiotensin Converting Enzyme 2 Rat Recombinant
ACE2 Rat produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 731 amino acids (18-740 aa) and having a molecular mass of 84.7kDa. ACE2 is fused to an 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Introduction
Angiotensin-converting enzyme 2 (ACE2) is a zinc-containing metalloenzyme that plays a crucial role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure and fluid balance . ACE2 can be found either attached to the membrane of cells (mACE2) or in a soluble form (sACE2) . It is classified as a carboxypeptidase and is a homolog of angiotensin-converting enzyme (ACE) .
Key Biological Properties: ACE2 acts as a peptidase, catalyzing the cleavage of angiotensin II (Ang II) into angiotensin (1-7), which has vasodilatory effects .
Expression Patterns and Tissue Distribution: ACE2 is primarily expressed in the heart, kidneys, lungs, testes, intestines, and adipose tissue . It is also found in the intestines, kidney, testis, gallbladder, and heart .
Primary Biological Functions: ACE2 counterbalances the effects of ACE by converting Ang II, a vasoconstrictor, into Ang (1-7), a vasodilator . This helps in lowering blood pressure and protecting organs from inflammatory injuries .
Role in Immune Responses and Pathogen Recognition: ACE2 serves as a functional receptor for coronaviruses, including SARS-CoV and SARS-CoV-2, facilitating viral entry into host cells . This makes it a critical player in immune responses and pathogen recognition.
Mechanisms with Other Molecules and Cells: ACE2 interacts with the spike protein of SARS-CoV-2, allowing the virus to enter and infect cells . It also binds to MasR receptors, creating localized vasodilation and decreasing blood pressure .
Binding Partners and Downstream Signaling Cascades: ACE2’s enzymatic activity leads to the production of Ang (1-7), which binds to MasR receptors, initiating signaling cascades that result in vasodilation and anti-inflammatory effects .
Biomedical Research: ACE2 is extensively studied for its role in cardiovascular diseases and as a receptor for SARS-CoV-2 .
Diagnostic Tools: ACE2 levels can be used as biomarkers for various diseases, including COVID-19 .
Therapeutic Strategies: Targeting ACE2 with inhibitors or activators is being explored for treating cardiovascular diseases and COVID-19 .
Development to Aging and Disease: ACE2 plays a vital role throughout the life cycle, from development to aging. It helps maintain cardiovascular health and protect organs from damage . In diseases like COVID-19, ACE2’s role as a viral receptor makes it a critical factor in disease progression and severity .
ACE2’s multifaceted roles in physiology and disease make it a significant focus of ongoing research, with potential applications in diagnostics and therapeutics.
