Enzymes
Product List
ALDOA Human
Aldolase-A Human Recombinant
ALDOB Human
Aldolase B Fructose-Bisphosphate Human Recombinant
ALDOB is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
ALDOC Human
Aldolase C Fructose-Bisphosphate Human Recombinant
ALDOC Human, Active
Aldolase C Fructose-Bisphosphate Human Recombinant, Active
ALDOC Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 364 amino acids (1-364 a.a.) and having a molecular mass of 39.4kDa.
The ALDOC is purified by proprietary chromatographic techniques.
ALDOC Human, His
Aldolase C Fructose-Bisphosphate Human Recombinant, His Tag
The ALDOC is purified by proprietary chromatographic techniques.
ALDOC Mouse
Aldolase C Fructose-Bisphosphate Mouse Recombinant
ALDOC is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
DERA
Deoxyribose-Phosphate Aldolase E.Coli Recombinant
DERA is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
DERA Human
Deoxyribose-Phosphate Aldolase Human Recombinant
DERA is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TALDO1 Human
Transaldolase Human Recombinant
Introduction
Aldolase is an enzyme that plays a crucial role in glycolysis, the metabolic pathway that converts glucose into pyruvate, generating energy in the form of ATP. It catalyzes the reversible conversion of fructose-1,6-bisphosphate into glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP) . Aldolase is classified into three isozymes: Aldolase A (ALDOA), Aldolase B (ALDOB), and Aldolase C (ALDOC), which are distinguished by their electrophoretic and catalytic properties .
Aldolase interacts with other molecules and cells through several mechanisms:
- Binding Partners: It binds to various molecules, including fructose-1,6-bisphosphate, to catalyze its conversion into G3P and DHAP .
- Downstream Signaling Cascades: Aldolase is involved in signaling pathways such as Wnt/β-catenin, EGFR/MAPK, Akt, and HIF-1α, which are crucial for cellular functions and responses .
The expression and activity of aldolase are tightly regulated through multiple mechanisms:
Aldolase has several applications in biomedical research and clinical settings:
- Biomedical Research: It is used as a biocatalyst in various biotechnological applications due to its high specificity and efficiency .
- Diagnostic Tools: Aldolase levels are measured in diagnostic tests to assess muscle and liver health .
- Therapeutic Strategies: Targeting aldolase has potential therapeutic applications, particularly in cancer treatment, where it can influence cancer cell metabolism and drug resistance .
Aldolase plays a significant role throughout the life cycle, from development to aging and disease:
- Development: Aldolase is essential for energy production during development, supporting growth and differentiation .
- Aging: Changes in aldolase activity and expression are associated with aging and age-related diseases .
- Disease: Dysregulation of aldolase is linked to various diseases, including cancer, where it contributes to metabolic reprogramming and tumor progression .
