Enzymes
Product List
TGFBR2 Human
Transforming Growth Factor Beta Receptor II Human Recombinant
TGFBR2 is purified by proprietary chromatographic techniques
TGFBR2 Human, His
Transforming Growth Factor Beta Receptor II, His Tag Human Recombinant
TGFBR2 is expressed with a 239aa hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
TGFBR1 Human
Transforming Growth Factor Beta Receptor I Human Recombinant
TGFBR1produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 342 amino acids (27-126a.a.) and having a molecular mass of 38.0kDa. (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
TGFBR1is expressed with a 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
TGFBR1 Human, Active
Transforming Growth Factor Beta Receptor 1 Human Recombinant, Active
TGFBR1 produced in Sf9 insect cells is a single, glycosylated polypeptide chain containing 342 amino acids (27-126a.a.) and having a molecular mass of 38kDa. TGFBR1 is expressed with 242 amino acid hIgG-His-Tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
Introduction
Transforming Growth Factor Beta Receptors (TGFBR) are a group of transmembrane serine/threonine kinase receptors that play a crucial role in the TGF-β signaling pathway. These receptors are classified into three main types: TGFBR1, TGFBR2, and TGFBR3. TGFBR1 and TGFBR2 are primarily involved in signal transduction, while TGFBR3, also known as betaglycan, acts as a co-receptor that enhances the binding of TGF-β ligands to TGFBR2 .
Key Biological Properties: TGFBRs are involved in various cellular processes, including cell growth, differentiation, apoptosis, and immune responses. They are ubiquitously expressed in almost all cell types and tissues .
Expression Patterns and Tissue Distribution: TGFBR1 and TGFBR2 are widely expressed in many tissues, including the lungs, liver, kidneys, and immune cells. TGFBR3 is predominantly found in the heart, lungs, and kidneys .
Primary Biological Functions: TGFBRs are essential for regulating cell proliferation, differentiation, and apoptosis. They play a significant role in maintaining tissue homeostasis and immune responses .
Role in Immune Responses and Pathogen Recognition: TGFBRs are involved in modulating immune responses by regulating the activity of various immune cells, including T-cells and macrophages. They help in pathogen recognition and the subsequent immune response .
Mechanisms with Other Molecules and Cells: TGFBRs interact with TGF-β ligands, leading to the formation of receptor complexes. TGFBR2 phosphorylates and activates TGFBR1, which then propagates the signal downstream .
Binding Partners and Downstream Signaling Cascades: Upon activation, TGFBR1 phosphorylates receptor-regulated SMAD proteins (R-SMADs), which then form complexes with co-SMADs and translocate to the nucleus to regulate gene expression .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of TGFBRs are tightly regulated at multiple levels, including transcriptional regulation and post-translational modifications such as phosphorylation and ubiquitination .
Transcriptional Regulation and Post-Translational Modifications: TGFBR signaling is modulated by various feedback loops and regulatory proteins that ensure the robustness, duration, and specificity of the signaling pathway .
Biomedical Research: TGFBRs are extensively studied in the context of cancer, fibrosis, and cardiovascular diseases. They are potential targets for therapeutic interventions .
Diagnostic Tools and Therapeutic Strategies: Antibodies targeting TGFBRs are used in diagnostic assays such as Western Blot, Immunohistochemistry, and ELISA. Therapeutic strategies include the development of small-molecule inhibitors and monoclonal antibodies .
Role Throughout the Life Cycle: TGFBRs play a critical role in various stages of the life cycle, from embryonic development to aging. They are involved in tissue homeostasis, wound healing, and the regulation of immune responses .
From Development to Aging and Disease: Dysregulation of TGFBR signaling is associated with various diseases, including cancer, fibrosis, and autoimmune disorders. Understanding the role of TGFBRs in these processes is crucial for developing effective therapeutic strategies .
