TGFBR1 Human, Active
Sf9, Baculovirus cells.
TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TGFR-1.
Greater than 90.0% as determined by SDS-PAGE.
Description
TGFBR1 produced in Sf9 insect cells is a single, glycosylated polypeptide chain containing 342 amino acids (27-126a.a.) and having a molecular mass of 38kDa. TGFBR1 is expressed with 242 amino acid hIgG-His-Tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TGFR-1.
Sf9, Baculovirus cells.
ADLLLPGATA LQCFCHLCTK DNFTCVTDGL CFVSVTETTD KVIHNSMCIA EIDLIPRDRP FVCAPSSKTG SVTTTYCCNQ DHCNKIELPT TVKSSPGLGP VELVEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL
PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH.
Product Science Overview
TGF-βR1 is a serine/threonine kinase receptor that, upon binding with its ligand, TGF-β, forms a heteromeric complex with TGF-βR2. This complex then phosphorylates and activates downstream signaling molecules, primarily the SMAD proteins, which translocate to the nucleus to regulate gene expression .
Recombinant human TGF-βR1 is produced using advanced biotechnological methods, often involving expression systems such as Escherichia coli or Chinese Hamster Ovary (CHO) cells. These systems allow for the production of high-purity, biologically active forms of the receptor, which are essential for research and therapeutic applications .
Recombinant TGF-βR1 is widely used in scientific research to study the TGF-β signaling pathway and its implications in various diseases, including cancer, fibrosis, and cardiovascular diseases. It is also utilized in drug development to screen for potential inhibitors or modulators of the TGF-β pathway .
