TGFBR2 Human
Description
TGFBR2 is purified by proprietary chromatographic techniques
Product Specs
Transforming growth factor, beta receptor II (TGFBR2) is a transmembrane receptor kinase that plays a critical role in the TGF-beta signaling pathway. This pathway is involved in regulating a wide range of cellular processes, including cell growth, differentiation, and apoptosis. TGFBR2 forms a heterodimeric complex with TGFBR1 upon binding of the TGF-beta ligand. This complex leads to the phosphorylation of downstream signaling molecules, ultimately resulting in the regulation of gene expression. Mutations in the TGFBR2 gene have been implicated in various diseases, including cancer and cardiovascular disorders.
In ELISA (enzyme-linked immunosorbent assay), concentrations of 0.5-1 μg/ml can be used for measuring TGF-beta levels.
Product Science Overview
TGFβR2 is a single-pass type I membrane protein that contains a protein kinase domain . It exists as a heterodimeric complex with another receptor protein and binds TGF-beta . The receptor is involved in the regulation of cell proliferation and other cellular responses triggered through the TGF-beta receptor complex .
The TGF-beta signaling pathway is initiated when TGF-beta ligands bind to TGFβR2. This binding causes TGFβR2 to recruit and phosphorylate TGFβR1, forming a heterotetrameric complex. The activated TGFβR1 then phosphorylates receptor-regulated SMADs (R-SMADs), which form a complex with SMAD4. This complex translocates to the nucleus, where it regulates the transcription of target genes involved in various cellular processes .
TGF-beta signaling is essential for numerous biological events, including embryogenesis, wound healing, and immune regulation . However, dysregulation of this pathway is associated with various pathologies, such as cancer, fibrosis, autoimmune diseases, and cardiovascular diseases . In cancer, TGF-beta acts as a tumor suppressor in early stages but promotes tumor growth and metastasis in later stages by supporting immune evasion and angiogenesis .
Due to its involvement in multiple critical processes, TGFβR2 is a promising target for therapeutic interventions. Targeting TGF-beta signaling pathways can potentially treat various conditions, including cancer, fibrosis, and autoimmune diseases . However, achieving cell specificity remains a challenge in developing effective therapies .
