CTSD Mouse

Mouse Cathepsin-D is synthesized as a precursor protein, consisting of:

• Signal peptide (residues 1-20)
• Propeptide (residues 21-64)
• Mature chain (residues 65-410)

The mature form of Cathepsin-D is responsible for its proteolytic activity. The recombinant version of mouse Cathepsin-D is often produced in cell lines, such as mouse myeloma cells, and is tagged for purification and detection purposes .

Cathepsin-D is involved in the normal degradation of proteins and the activation of precursors of bioactive proteins in pre-lysosomal compartments . It is particularly important in the breakdown of amyloid-β protein (Aβ) and the microtubule-associated protein tau, both of which are implicated in Alzheimer’s disease .

Research has shown that Cathepsin-D plays a significant role in the pathogenesis of Alzheimer’s disease. Genetic deletion of Cathepsin-D in mice leads to the accumulation of amyloid-β and tau proteins, which are hallmark features of Alzheimer’s disease . This suggests that Cathepsin-D is crucial for maintaining the proteostasis of these proteins in vivo.

Recombinant mouse Cathepsin-D is used in various research applications, including:

• Studying protein degradation pathways
• Investigating the role of Cathepsin-D in diseases like Alzheimer’s
• Developing potential therapeutic interventions

The recombinant protein is typically purified to high levels of purity and is available in carrier-free formulations to avoid interference in experimental assays .