CCNG1 Human
Description
CCNG1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Cyclin G1 is a member of the cyclin family, which plays a crucial role in regulating the cell cycle. Cyclins are proteins that control the progression of cells through the cell cycle by activating cyclin-dependent kinases (CDKs). Cyclin G1, in particular, is involved in the regulation of the G1 phase of the cell cycle, which is the first phase in the cell cycle that leads to cell division.
Cyclin G1 is characterized by its cyclical expression pattern, which is tightly regulated during the cell cycle. It forms complexes with CDKs, particularly CDK2 and CDK4, to control the transition from the G1 phase to the S phase, where DNA replication occurs. The activity of Cyclin G1 is essential for the proper timing of cell cycle events and ensuring that cells only divide when they are ready.
Human recombinant Cyclin G1 is a form of the protein that is produced using recombinant DNA technology. This involves inserting the gene that encodes Cyclin G1 into a host organism, such as bacteria or yeast, which then produces the protein. This method allows for the production of large quantities of Cyclin G1 for research and therapeutic purposes.
Cyclin G1 has been extensively studied in the context of cancer research. Abnormal regulation of Cyclin G1 and its associated CDKs can lead to uncontrolled cell proliferation, a hallmark of cancer. Understanding the mechanisms by which Cyclin G1 regulates the cell cycle can provide insights into potential therapeutic targets for cancer treatment.
Human recombinant Cyclin G1 is used in various research applications, including:
- Cell Cycle Studies: Researchers use Cyclin G1 to study the regulation of the cell cycle and identify potential points of intervention for cancer therapy.
- Drug Development: Cyclin G1 is used in screening assays to identify compounds that can modulate its activity, which may lead to the development of new cancer treatments.
- Biotechnology: The production of recombinant Cyclin G1 is an example of how recombinant DNA technology can be used to produce proteins for research and therapeutic use.
