Enzymes
Product List
CTSL Mouse
Cathepsin-L Mouse Recombinant
CTSS Human
Cathepsin-S Human Recombinant
CTSS Mouse
Cathepsin-S Mouse Recombinant
CTSS is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
CTSW Human
Cathepsin-W Human Recombinant
CTSZ Human
Cathepsin-Z Human Recombinant
CTSZ is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CTSZ Human, Sf9
Cathepsin-Z Human Recombinant, Sf9
CTSZ is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
CTSZ Mouse
Cathepsin-Z Mouse Recombinant
CTSZ Mouse, Active
Cathepsin-Z, Active Mouse Recombinant
CTSZ Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 292 amino acids (23-306 aa) and having a molecular mass of 32.8kDa.
CTSZ is fused to a 8 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
Introduction
Cathepsins are a family of proteases (enzymes that degrade proteins) found in all animals and other organisms. The term “cathepsin” is derived from the Greek words “kata-” meaning “down” and “hepsein” meaning "boil" . These enzymes are primarily located in lysosomes, where they play a crucial role in protein degradation. Cathepsins are classified into three main types based on their catalytic mechanisms: cysteine proteases, aspartic proteases, and serine proteases .
Cathepsins are involved in several primary biological functions:
The expression and activity of cathepsins are tightly regulated through several mechanisms:
- Transcriptional Regulation: Gene expression of cathepsins is controlled by transcription factors.
- Post-Translational Modifications: Cathepsins undergo modifications such as glycosylation, which affect their stability and activity .
- Endogenous Inhibitors: Proteins like stefins, cystatins, and serpins regulate cathepsin activity by inhibiting their proteolytic functions .
Cathepsins have significant applications in biomedical research, diagnostics, and therapeutics:
- Biomedical Research: They are studied for their roles in various diseases, including cancer and cardiovascular diseases .
- Diagnostic Tools: Differential expression of cathepsins can serve as biomarkers for disease progression .
- Therapeutic Strategies: Selective inhibitors of cathepsins are being developed as potential treatments for diseases .
Cathepsins play vital roles throughout the life cycle, from development to aging and disease:
- Development: They are involved in tissue remodeling during embryogenesis and development .
- Aging: Cathepsin activity is linked to the degradation of cellular components, which is crucial for maintaining cellular homeostasis .
- Disease: Dysregulated cathepsin activity is associated with various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases .
