Enzymes
Product List
PDE6H Human
Phosphodiesterase 6H cGMP-Specific Cone Gamma Human Recombinant
PPME1 Human
Protein Phosphatase Methylesterase 1 Human Recombinant
The PPME1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
TDP1 Human
Tyrosyl-DNA Phosphodiesterase 1 Human Recombinant
TDP2 Human
Tyrosyl-DNA Phosphodiesterase 2 Human Recombinant
TDP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
YOD1 Human
YOD1 Human Recombinant
YOD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Esterases exhibit diverse biological properties, including broad substrate specificity and stability under various conditions. They are expressed in multiple tissues, including the liver, blood plasma, and various microbial environments . Their tissue distribution is extensive, with significant roles in lipid metabolism and detoxification processes .
Esterases play crucial roles in various biological functions:
Esterases interact with other molecules and cells through specific binding partners and downstream signaling cascades. The catalytic mechanism typically involves a serine residue in the active site, which attacks the carbonyl carbon of the ester bond, facilitated by histidine and aspartic/glutamic acid residues . This leads to the formation of an acyl-enzyme intermediate, which is subsequently hydrolyzed to release the products .
The expression and activity of esterases are regulated through various mechanisms:
- Transcriptional Regulation: Gene expression is controlled by transcription factors and regulatory elements in the promoter regions .
- Post-Translational Modifications: Esterase activity can be modulated by phosphorylation, glycosylation, and other modifications .
- Environmental Factors: pH, temperature, and the presence of inhibitors or activators can influence esterase activity .
Esterases have numerous applications in biomedical research, diagnostics, and therapeutics:
- Biomedical Research: Used as tools to study lipid metabolism and enzyme kinetics .
- Diagnostic Tools: Employed in assays to detect specific ester substrates or products .
- Therapeutic Strategies: Targeted for drug development, particularly in the treatment of metabolic disorders and detoxification therapies .
Throughout the life cycle, esterases play vital roles from development to aging and disease:
- Development: Involved in the regulation of lipid metabolism during growth and development .
- Aging: Changes in esterase activity are associated with aging processes and age-related diseases .
- Disease: Altered esterase activity is linked to various diseases, including metabolic disorders, neurodegenerative diseases, and cancer .
