Growth Factors
Product List
PDGF BB Human, Yeast
Platelet Derived Growth Factor-BB Human Recombinant, Yeast
PDGF-BB is purified by proprietary chromatographic techniques.
PDGF BB Human
Platelet-Derived Growth Factor BB Human Recombinant
PDGF BB Mouse
Platelet-Derived Growth Factor BB Mouse Recombinant
Platelet-Derived Growth Factor BB Mouse Recombinant produced in E.coli, is a homodimeric, non-glycosylated, polypeptide chain containing 2x110 (total of 2 chains 220aa) amino acids and having a total molecular weight of 24.7 kDa.
PDGF-BB is purified by proprietary chromatographic techniques.
PDGF BB Rat
Platelet-Derived Growth Factor BB Rat Recombinant
The PDGF-BB is purified by proprietary chromatographic techniques.
PDGF CC Human
Platelet Derived Growth Factor-CC Human Recombinant
The PDGF-CC is fused to a 7 amino acid His tag [M-HHHHHH] at N-terminal and purified by proprietary chromatographic techniques.
PDGF-BB Equine
Platelet Derived Growth Factor-BB Equine Recombinant
PDGF-BB Equine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide dimer chain containing 2 x 110 amino acids and having a total molecular mass of 24.8kDa.
The PDGF-BB is purified by proprietary chromatographic techniques.
Escherichia Coli.
PDGFD Human
Platelet Derived Growth Factor-D Human Recombinant
PDGFD is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
PDGFRA Human
Platelet-Derived Growth Factor Receptor, Alpha Human Recombinant
The PDGFRA is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
PDGFRB Human
Platelet-Derived Growth Factor Receptor, Beta Human Recombinant
PDGFRB produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 739 amino acids (33-532a.a.) and having a molecular mass of 83.3kDa (Molecular size on SDS-PAGE will appear at approximately 100-150kDa).
PDGFRB is expressed with an 239 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Insect cells.
Sterile filtered colorless solution.
PDGF A Human
Platelet-Derived Growth Factor A Human Recombinant
PDGF-A is purified by proprietary chromatographic techniques.
Introduction
Platelet-Derived Growth Factor (PDGF) is a family of growth factors that regulate cell growth and division. PDGF is a dimeric glycoprotein composed of two subunits, which can be either identical (homodimers) or different (heterodimers). The five known isoforms of PDGF are PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD, and PDGF-AB . These isoforms interact with two types of tyrosine kinase receptors, PDGFRα and PDGFRβ .
PDGF is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells, and glial cells . It is synthesized, stored in the alpha granules of platelets, and released upon platelet activation . PDGF is also produced by other cells such as smooth muscle cells, activated macrophages, and endothelial cells . The expression patterns and tissue distribution of PDGF vary, with significant roles in blood vessel formation, cell proliferation, and chemotaxis .
PDGF plays a crucial role in various biological processes, including cell proliferation, survival, migration, and differentiation . It is involved in tissue remodeling, cellular differentiation, and inductive events in patterning and morphogenesis . PDGF also contributes to immune responses and pathogen recognition by regulating the activity of immune cells .
PDGF exerts its effects by binding to its receptors, PDGFRα and PDGFRβ, on the cell surface . Upon binding, these receptors dimerize and undergo autophosphorylation, activating downstream signaling cascades such as the PI3K pathway and reactive oxygen species (ROS)-mediated activation of the STAT3 pathway . These signaling pathways lead to various cellular responses, including changes in cell shape, motility, and gene expression .
The expression and activity of PDGF are tightly regulated at multiple levels. Transcriptional regulation involves various transcription factors that bind to the promoter regions of PDGF genes . Post-translational modifications, such as phosphorylation and glycosylation, also play a role in modulating PDGF activity . Additionally, feedback mechanisms and interactions with other signaling pathways contribute to the fine-tuning of PDGF signaling .
PDGF has numerous applications in biomedical research, diagnostics, and therapeutics. It is used in medicine to promote the healing of chronic ulcers and in orthopedic surgery and periodontics to stimulate bone regeneration and repair . PDGF is also being investigated for its potential in treating neurodegenerative diseases, such as Parkinson’s disease, due to its neurotrophic properties .
Throughout the life cycle, PDGF plays a vital role in development, aging, and disease. During embryonic development, PDGF drives the proliferation and differentiation of mesenchymal cells and progenitor populations . In adulthood, PDGF is involved in tissue maintenance and repair . Overexpression of PDGF has been linked to various diseases, including atherosclerosis, fibrotic disorders, and malignancies .
