Growth Factors
Product List
AREG Human
Amphiregulin Human Recombinant
The AREG is purified by proprietary chromatographic techniques.
BMP8B Human
Bone Morphogenetic protein-8b Human Recombinant
BMP8B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
LFA 3 Human
Lymphocyte Function Associated Antigen-3 Human Recombinant , Fusion Protein
Recombinant LFA3 is purified by proprietary chromatographic techniques.
MYDGF Mouse
Myeloid Derived Growth Factor Mouse Recombinant
MYDGF Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (25-166 a.a) and having a molecular mass of 18.1kDa.
MYDGF is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
OSTF1 Human
Osteoclast Stimulating Factor-1 Human Recombinant
The OSTF1 is fused to an 8 amino acid His Tag at C-terminus & purified by proprietary chromatographic techniques.
PGRN Human
Progranulin Human Recombinant
Progranulin Human Recombinant produced in HEK is a single, glycosylated, polypeptide chain containing 1-593 amino acids and having a molecular mass of 74kDa. The Progranulin is purified by standard chromatographic techniques.
Sterile Filtered White lyophilized (freeze-dried) powder.
Introduction
Growth factors are naturally occurring proteins capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. They play crucial roles in various biological processes. Other growth factors refer to those that do not fall under the well-known categories like epidermal growth factor (EGF), fibroblast growth factor (FGF), or transforming growth factor (TGF). These include factors like hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF).
- Key Biological Properties: Other growth factors are involved in cell signaling, promoting cell survival, proliferation, and differentiation. They often act in a paracrine or autocrine manner.
- Expression Patterns: These growth factors are expressed in various tissues and organs, often in response to specific physiological needs or injury.
- Tissue Distribution: For example, HGF is primarily produced by mesenchymal cells, VEGF by endothelial cells, and PDGF by platelets and endothelial cells.
- Primary Biological Functions:
- HGF: Promotes liver regeneration, cell motility, and morphogenesis.
- VEGF: Stimulates angiogenesis (formation of new blood vessels).
- PDGF: Involved in wound healing and the development of blood vessels.
- Role in Immune Responses: These growth factors can modulate immune responses by influencing the behavior of immune cells.
- Pathogen Recognition: Some growth factors can enhance the ability of immune cells to recognize and respond to pathogens.
- Mechanisms with Other Molecules and Cells: Growth factors bind to specific receptors on the surface of target cells, initiating a cascade of intracellular signaling.
- Binding Partners: Each growth factor has specific receptors, such as the c-Met receptor for HGF, VEGFR for VEGF, and PDGFR for PDGF.
- Downstream Signaling Cascades: Activation of these receptors triggers signaling pathways like the MAPK/ERK pathway, PI3K/AKT pathway, and JAK/STAT pathway, leading to various cellular responses.
- Control of Expression and Activity: The expression of growth factors is tightly regulated at the transcriptional level by various transcription factors and signaling molecules.
- Transcriptional Regulation: Factors like hypoxia-inducible factor (HIF) can upregulate VEGF expression under low oxygen conditions.
- Post-Translational Modifications: Growth factors can undergo modifications such as phosphorylation, glycosylation, and proteolytic cleavage, affecting their activity and stability.
- Biomedical Research: Growth factors are used to study cell signaling, development, and disease mechanisms.
- Diagnostic Tools: Levels of certain growth factors can serve as biomarkers for diseases like cancer and cardiovascular conditions.
- Therapeutic Strategies: Growth factors are used in regenerative medicine, such as HGF for liver regeneration, VEGF for promoting angiogenesis in ischemic tissues, and PDGF in wound healing therapies.
- Development: Growth factors are crucial during embryonic development, guiding the formation of tissues and organs.
- Aging: The activity of growth factors can decline with age, contributing to reduced tissue regeneration and repair.
- Disease: Dysregulation of growth factors is associated with various diseases, including cancer, where overexpression can lead to uncontrolled cell proliferation, and chronic wounds, where insufficient growth factor activity impairs healing.
