Growth Factors
Product List
Leptin tA Ovine
Leptin Antagonist Triple Mutant Ovine Recombinant
Leptin Bovine
Leptin Bovine Recombinant
The Leptin is purified by proprietary chromatographic techniques.
Leptin Chicken
Leptin Chicken Recombinant
The Leptin is purified by proprietary chromatographic techniques.
Leptin Dog
Leptin Dog Recombinant
The Leptin is purified by proprietary chromatographic techniques.
Leptin Horse
Leptin Horse Recombinant
The Leptin is purified by proprietary chromatographic techniques.
Leptin Human
Human Leptin
Leptin Human, His
Leptin Human Recombinant, His Tag
The Leptin is purified by proprietary chromatographic techniques.
Leptin Human, N82K
Leptin Human Recombinant, N82K
Leptin N82K Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 146 amino acids (and additional Ala at N-terminus acids) and having a molecular mass of 16kDa.
The Leptin N82K is purified by proprietary chromatographic techniques.
Leptin Human, N82K PEG
Leptin N82K Human Recombinant, Pegylated
Pegylated Leptin N82K Human Recombinant produced in E.Coli is a single non-glycosilated polypeptide chain containing 146 amino acids, an additional Ala at N-terminus and one molecule of PEG 20 kDa at its N-terminus acids and having a molecular weight of 35.6kDa. However due to enlarged hydrodymanic volume it runs on the SDS-PAGE as 48 kDa protein and in gel-filtration on Superdex 200 as over 200 kDa protein. Pegylated Leptin N82K Human Recombinant was purified by proprietary chromatographic techniques.
Leptin Mouse
Leptin Mouse Recombinant
Leptin Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 147 amino acids and having a molecular mass of 16 kDa. The Leptin is purified by proprietary chromatographic techniques.
Introduction
Key Biological Properties: Leptin is a 16-kDa circulating hormone that acts as a major regulator for food intake and energy homeostasis .
Expression Patterns: Leptin is primarily expressed in white adipose tissue but is also produced in smaller amounts by other tissues such as the stomach, placenta, and mammary gland .
Tissue Distribution: Leptin receptors are widely distributed in the brain, particularly in the hypothalamus, as well as in peripheral tissues including the liver, skeletal muscle, and immune cells .
Primary Biological Functions: Leptin’s main function is to regulate long-term energy balance by inhibiting hunger and controlling energy expenditure . It also plays a role in metabolism, endocrine system regulation, and immune system function .
Role in Immune Responses and Pathogen Recognition: Leptin influences immune responses by modulating the activity of immune cells, including T cells and macrophages . It has been shown to enhance the body’s ability to recognize and respond to pathogens .
Mechanisms with Other Molecules and Cells: Leptin acts via its receptor, LepRb, on specialized neuronal populations in the brain, mainly in the hypothalamus and brainstem .
Binding Partners: Leptin binds to its receptor LepRb, which is expressed by various cell types in the brain and peripheral tissues .
Downstream Signaling Cascades: Upon binding to its receptor, leptin activates several downstream signaling pathways, including the JAK/STAT pathway, MAP kinase, and PI-3 kinase pathways .
Control of Expression and Activity: Leptin expression and protein levels are regulated by multiple factors, including hormones such as insulin, glucocorticoids, and catecholamines .
Transcriptional Regulation: The transcription of the LEP gene is influenced by various metabolic and hormonal signals .
Post-Translational Modifications: Leptin undergoes post-translational modifications that affect its stability and activity .
Biomedical Research: Leptin is extensively studied in the context of obesity, diabetes, and metabolic disorders .
Diagnostic Tools: Leptin levels can be measured to assess metabolic health and diagnose conditions such as leptin deficiency .
Therapeutic Strategies: Leptin replacement therapy is used to treat conditions like congenital leptin deficiency and lipodystrophy .
Development to Aging and Disease: Leptin plays a critical role throughout the life cycle, from fetal development to aging . It influences growth, reproductive function, and immune responses . Dysregulation of leptin levels is associated with various diseases, including obesity, diabetes, and neurodegenerative disorders .
