Growth Factors
Product List
OSM Human
Oncostatin-M Human Recombinant
The OSM is purified by proprietary chromatographic techniques.
OSM Human, 195 a.a
Oncostatin-M Human Recombinant (195 a.a.)
The OSM is purified by proprietary chromatographic techniques.
OSM Human, 209 a.a
Oncostatin M Human Recombinant (209 a.a.)
The Oncostatin-M (209 a.a.) is purified by proprietary chromatographic techniques.
OSM Human, His
Oncostatin-M Human Recombinant, His Tag
The OSM is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
OSM Mouse
Oncostatin-M Mouse Recombinant
The OSM is purified by proprietary chromatographic techniques.
OSM Rat
Oncostatin-M Rat Recombinant
The OSM is purified by proprietary chromatographic techniques.
Introduction
Key Biological Properties: OSM is known for its cytokine activity, receptor binding, and growth factor activity . It plays a significant role in various biological processes, including immune response, cell proliferation, and inflammation .
Expression Patterns and Tissue Distribution: OSM is expressed in various tissues, including bone marrow cells, monocytes, blood, nasal epithelium, appendix, granulocytes, gallbladder, and spleen . It is also found in the central nervous system (CNS), where it interacts with CNS resident cells .
Primary Biological Functions: OSM is involved in hematopoiesis, neuropoiesis, inflammation, bone remodeling, muscle proliferation, and embryonic development . It also plays a role in immune responses and pathogen recognition .
Role in Immune Responses and Pathogen Recognition: OSM is crucial in the immune system’s communication and signaling, particularly in the CNS . It helps in the regulation of inflammatory responses and immune surveillance .
Mechanisms with Other Molecules and Cells: OSM primarily activates the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway, and other physiological processes .
Binding Partners and Downstream Signaling Cascades: OSM binds to receptors via two binding sites named site II and site III . It signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, while the type II receptor is composed of gp130 and OSMR .
Regulatory Mechanisms Controlling Expression and Activity: OSM expression and activity are regulated through various signaling pathways, including JAK/STAT, MAPK, JNK, and PI3K/AKT pathways . These pathways are crucial for its role in inflammation, immune response, and cell proliferation .
Transcriptional Regulation and Post-Translational Modifications: OSM’s regulatory mechanisms involve transcriptional regulation and post-translational modifications, which are essential for its diverse biological functions .
