Growth Factors
Product List
CTGF (182-250 a.a.) Human
Connective Tissue Growth Factor Human Recombinant (182-250 a.a.)
CTGF Human
Connective Tissue Growth Factor Human Recombinant
The CTGF is purified by proprietary chromatographic techniques.
CTGF Human (183-255)
Connective Tissue Growth Factor (183-255 a.a.) Human Recombinant
CTGF Human Recombinant is a single, glycosylated polypeptide chain containing 80 amino acids (183-255a.a) and having a molecular mass of 9.1kDa (calculated). CTGF is fused to a 7 a.a His tag at N-terminal.
HEK293 cells.
CTGF Human, HEK
Connective Tissue Growth Factor Human Recombinant , HEK
CTGF Human, His
Connective Tissue Growth Factor Human Recombinant, His Tag
The CTGF is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Introduction
Connective Tissue Growth Factor (CTGF), also known as cellular communication network factor 2 (CCN2), is a matricellular protein belonging to the CCN family of extracellular matrix-associated heparin-binding proteins . It plays a crucial role in various biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair .
Key Biological Properties: CTGF is a cysteine-rich protein with four conserved domains: the insulin-like growth factor binding protein (IGFBP) domain, the von Willebrand type C repeats (vWC) domain, the thrombospondin type 1 repeat (TSR) domain, and a C-terminal domain (CT) with a cysteine knot motif .
Expression Patterns: CTGF is expressed in various tissues, including connective tissues, skin, and organs such as the liver and kidneys . Its expression is crucial during embryonic development and is also detected in several adulthood diseases .
Tissue Distribution: CTGF is widely distributed in tissues involved in wound healing and fibrotic processes, such as the skin, liver, kidneys, and lungs .
Primary Biological Functions: CTGF is involved in cell adhesion, migration, proliferation, angiogenesis, and tissue repair . It plays a significant role in fibrotic diseases and various forms of cancer .
Role in Immune Responses and Pathogen Recognition: CTGF contributes to immune responses by modulating the activity of immune cells and influencing the extracellular matrix, which can affect pathogen recognition and response .
Mechanisms with Other Molecules and Cells: CTGF exerts its functions by binding to various cell surface receptors, including integrin receptors, heparan sulfate proteoglycans (HSPGs), low-density lipoprotein receptor-related proteins (LRPs), and tropomyosin receptor kinase A (TrkA) . It also interacts with growth factors and extracellular matrix proteins .
Binding Partners and Downstream Signaling Cascades: CTGF binds to aggrecan, vascular endothelial growth factor (VEGF), and members of the transforming growth factor-beta (TGF-β) superfamily . These interactions activate downstream signaling cascades that regulate cell proliferation, migration, and differentiation .
Transcriptional Regulation: The expression of CTGF is regulated by various transcription factors and signaling pathways, including TGF-β, which can induce CTGF expression .
Post-Translational Modifications: CTGF undergoes post-translational modifications, such as phosphorylation and glycosylation, which can influence its activity and interactions with other molecules .
Biomedical Research: CTGF is a valuable target in biomedical research due to its involvement in fibrosis, cancer, and tissue repair .
Diagnostic Tools: Elevated levels of CTGF can serve as biomarkers for fibrotic diseases and certain cancers .
Therapeutic Strategies: Targeting CTGF with specific inhibitors or monoclonal antibodies has shown promise in treating fibrotic diseases and cancer .
Development: CTGF is essential for embryonic development, particularly in skeletal development and angiogenesis . Knockout mice with disrupted CTGF genes exhibit severe developmental defects and perinatal lethality .
Aging and Disease: In adulthood, CTGF is associated with wound healing and fibrotic diseases . Its overexpression can lead to fibrosis in various organs, including the skin, kidneys, and lungs . CTGF also plays a role in cancer progression and metastasis .
