Growth Factors
Product List
HDGF Human
Hepatoma-Derived Growth Factor Human Recombinant
The HDGF is purified by proprietary chromatographic techniques.
HDGF2 Human
Hepatoma-Derived Growth Factor-2 Human Recombinant
HDGF2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
HDGFL1 Human
Hepatoma Derived Growth Factor-Like 1 Human Recombinant
HDGFL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Hepatoma-Derived Growth Factor (HDGF) is a protein encoded by the HDGF gene in humans. It was initially identified as a novel growth factor for hepatoma cells and is also known as high mobility group protein 1-like 2 (HMG-1L2) . HDGF belongs to a family of proteins that includes several HDGF-related proteins, which are characterized by their heparin-binding properties and roles in cellular growth and development .
HDGF exhibits several key biological properties:
- Expression Patterns: HDGF is ubiquitously expressed in various non-cancerous tissues, including the liver, kidney, cardiovascular system, and brain .
- Tissue Distribution: It is found in both fetal and adult tissues, with higher expression levels observed in certain cancers .
- Key Biological Properties: HDGF has mitogenic, angiogenic, and anti-apoptotic activities. It promotes cellular proliferation, differentiation, and migration .
HDGF plays several primary biological functions:
- Cell Growth and Proliferation: HDGF stimulates the growth of various cell types, including hepatoma cells .
- Angiogenesis: It induces the formation of new blood vessels, which is crucial for tissue repair and tumor growth .
- Anti-Apoptotic Role: HDGF helps in preventing programmed cell death, thereby supporting cell survival .
- Role in Immune Responses and Pathogen Recognition: While HDGF’s direct role in immune responses and pathogen recognition is not well-documented, its involvement in cellular growth and repair indirectly supports immune functions .
HDGF interacts with other molecules and cells through various mechanisms:
The expression and activity of HDGF are regulated through multiple mechanisms:
HDGF has several applications in biomedical research and clinical practice:
- Biomedical Research: HDGF is studied for its role in cancer progression and as a potential therapeutic target .
- Diagnostic Tools: HDGF levels can serve as biomarkers for certain cancers, aiding in diagnosis and prognosis .
- Therapeutic Strategies: Targeting HDGF or its signaling pathways offers potential therapeutic approaches for treating cancers and other diseases .
HDGF plays a role throughout the life cycle, from development to aging and disease:
- Development: HDGF is involved in the development of various organs and tissues during embryogenesis .
- Aging: Its expression and activity may change with age, influencing tissue repair and regeneration .
- Disease: HDGF is implicated in the progression of several cancers and other diseases, making it a critical factor in disease development and progression .
