Growth Factors
Product List
KGF 2 His Human
Keratinocyte Growth Factor-2 Human Recombinant, His Tag
KGF 2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
KGF 2 Human
Keratinocyte Growth Factor-2 Human Recombinant
The FGF10 is purified by proprietary chromatographic techniques.
KGF 2 Mouse
Keratinocyte Growth Factor-2 Mouse Recombinant
The KGF 2 is purified by proprietary chromatographic techniques.
KGF 2 Rat
Keratinocyte Growth Factor-2 Rat Recombinant
The KGF 2 is purified by proprietary chromatographic techniques.
KGF Human
Keratinocyte Growth Factor Human Recombinant
The FGF-7 is purified by proprietary chromatographic techniques.
KGF Human, Plant
Keratinocyte Growth Factor Human Recombinant, Plant
KGF Human Recombinant produced in Oryza Sativa is a single, polypeptide chain having a molecular mass of approximately 19.2kDa. The KGF is purified by proprietary chromatographic techniques.
Rice Grain
KGF Mouse
Keratinocye Growth Factor Mouse Recombinant
Introduction
Keratinocyte Growth Factor (KGF), also known as Fibroblast Growth Factor 7 (FGF7), is a member of the fibroblast growth factor family. It is a potent mitogen specifically for epithelial cells, including keratinocytes, which are the predominant cell type in the epidermis . KGF is produced by mesenchymal cells and acts predominantly in a paracrine manner .
Key Biological Properties: KGF is a small signaling molecule that binds to the fibroblast growth factor receptor 2b (FGFR2b) . It regulates the migration and differentiation of epithelial cells and protects them from various insults under stress conditions .
Expression Patterns and Tissue Distribution: KGF is produced by mesenchymal cells and its receptor, FGFR2-IIIb, is expressed by various epithelial cells, including epidermal keratinocytes, intestinal epithelial cells, and hepatocytes . After acute injury, KGF expression is strongly up-regulated in various tissues, including the skin and bladder .
Primary Biological Functions: KGF plays a crucial role in wound healing by promoting the proliferation, migration, and differentiation of epithelial cells . It also helps in protecting epithelial cells from damage and stress .
Role in Immune Responses and Pathogen Recognition: While KGF’s primary role is in epithelial cell regulation, it indirectly supports immune responses by maintaining the integrity of epithelial barriers, which are the first line of defense against pathogens .
Mechanisms with Other Molecules and Cells: KGF exerts its biological effects by binding to its high-affinity receptor, FGFR2-IIIb . This binding triggers downstream signaling cascades that promote cell proliferation, migration, and differentiation .
Binding Partners and Downstream Signaling Cascades: The interaction between KGF and FGFR2-IIIb activates several downstream signaling pathways, including the MAPK/ERK pathway, which is crucial for cell proliferation and survival .
Regulatory Mechanisms Controlling Expression and Activity: KGF expression is regulated by various factors, including endocrine hormones such as estrogen and LH . These hormones can stimulate KGF gene expression in mesenchymal cells .
Transcriptional Regulation and Post-Translational Modifications: The transcriptional regulation of KGF involves various signaling molecules and pathways that respond to cellular stress and injury . Post-translational modifications, such as phosphorylation, also play a role in modulating KGF activity .
Biomedical Research: KGF is widely studied for its role in epithelial cell biology and wound healing . It is also being evaluated for its potential in treating conditions like oral mucositis resulting from cancer chemoradiotherapy .
Diagnostic Tools and Therapeutic Strategies: KGF has potential applications in developing diagnostic tools for epithelial cell-related conditions and therapeutic strategies for enhancing wound healing and protecting epithelial tissues .
Role Throughout the Life Cycle: KGF plays a vital role throughout the life cycle, from development to aging and disease . During development, it supports the growth and differentiation of epithelial tissues . In adulthood, it helps maintain epithelial integrity and promotes wound healing . In aging and disease, KGF expression can be altered, affecting tissue repair and regeneration .
