Growth Factors
Product List
HGF (32-285) Human
Hepatoma-Derived Growth Factor (32-285 a.a) Human Recombinant
HGF B Human
Hepatocyte Growth Factor B Chain Human Recombinant
The HGF-B is purified by proprietary chromatographic techniques.
HGF Human
Hepatocyte Growth Factor Human Recombinant
The HGF is purified by proprietary chromatographic techniques.
HGF Human, CHO
Hepatocyte Growth Factor Human Recombinant, CHO
Hepatocyte Growth Factor Human Recombinant produced in CHO is a heterodimer, non-glycosylated, polypeptide chain consisting an a-chain of 463 amino acids and b-chain of 234 having a total molecular mass of approximately 75kDa.
The HGF is purified by proprietary chromatographic techniques.
Sterile Filtered White lyophilized (freeze-dried) powder.
HGF Human, HEK
Hepatocyte Growth Factor Human Recombinant, HEK
HGF Human Recombinant produced in HEK cells is a glycosylated disulfide-linked heterodimer, containing 697 a.a. (Gln-32 to Ser-728) having a total molecular weight of 80kDa.
The HGF is purified by proprietary chromatographic techniques.
HGF Mouse
Hepatocyte Growth Factor Mouse Recombinant
HGF Mouse Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 1146 amino acids (25-931aa) and having a molecular mass of 127.8kDa. HGF is fused to a 239 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
pHGF Porcine
Hepatocyte promoting Growth Factor Porcine
The HGF is purified by proprietary chromatographic techniques.
Introduction
Hepatocyte Growth Factor (HGF) is a multifunctional protein that plays a critical role in various biological processes. It is classified as a growth factor and is also known as scatter factor (SF). HGF is a member of the plasminogen-related growth factor family and is primarily produced by mesenchymal cells.
Key Biological Properties: HGF is a heterodimeric molecule composed of an alpha-chain and a beta-chain linked by a disulfide bond. It is secreted as an inactive precursor (pro-HGF) and is activated by proteolytic cleavage.
Expression Patterns: HGF is expressed in various tissues, including the liver, kidneys, lungs, and the nervous system. Its expression is regulated by various factors, including cytokines, growth factors, and hormones.
Tissue Distribution: HGF is widely distributed in the body, with high concentrations found in the liver, where it plays a crucial role in liver regeneration and repair. It is also present in other tissues such as the kidneys, lungs, and the nervous system.
Primary Biological Functions: HGF is involved in a wide range of biological functions, including cell proliferation, differentiation, motility, and survival. It is essential for embryonic development, tissue regeneration, and wound healing.
Role in Immune Responses: HGF modulates immune responses by influencing the behavior of various immune cells, including macrophages, dendritic cells, and T cells. It has anti-inflammatory properties and can promote tissue repair and regeneration in response to injury.
Pathogen Recognition: HGF can enhance the ability of immune cells to recognize and respond to pathogens, thereby contributing to the body’s defense mechanisms.
Mechanisms with Other Molecules and Cells: HGF exerts its effects by binding to its receptor, c-Met, a tyrosine kinase receptor. This binding triggers a cascade of downstream signaling events that mediate various cellular responses.
Binding Partners: HGF interacts with several binding partners, including heparan sulfate proteoglycans, which facilitate its binding to the c-Met receptor and enhance its biological activity.
Downstream Signaling Cascades: Upon binding to c-Met, HGF activates multiple signaling pathways, including the PI3K/Akt, MAPK/ERK, and STAT pathways. These pathways regulate various cellular processes, such as proliferation, survival, and migration.
Regulatory Mechanisms that Control Expression and Activity: The expression and activity of HGF are tightly regulated at multiple levels, including transcriptional, post-transcriptional, and post-translational mechanisms.
Transcriptional Regulation: HGF gene expression is regulated by various transcription factors, including NF-κB, AP-1, and STAT3. These factors can be activated by cytokines, growth factors, and other signaling molecules.
Post-Translational Modifications: HGF undergoes several post-translational modifications, including proteolytic cleavage, glycosylation, and phosphorylation. These modifications are essential for its activation, stability, and biological activity.
Biomedical Research: HGF is widely studied in biomedical research due to its diverse biological functions and therapeutic potential. It is used as a model to study cell signaling, tissue regeneration, and cancer biology.
Diagnostic Tools: HGF levels can serve as biomarkers for various diseases, including liver disease, kidney disease, and cancer. Measuring HGF levels in biological samples can aid in the diagnosis and prognosis of these conditions.
Therapeutic Strategies: HGF has therapeutic potential in regenerative medicine and tissue engineering. It is being explored as a treatment for liver cirrhosis, myocardial infarction, and chronic kidney disease. Additionally, HGF-based therapies are being developed for cancer treatment due to its ability to inhibit tumor growth and metastasis.
Development: HGF plays a crucial role in embryonic development, particularly in the formation of the liver, kidneys, and nervous system. It regulates cell proliferation, differentiation, and migration during organogenesis.
Aging: HGF levels decline with age, which may contribute to the reduced regenerative capacity of tissues in older individuals. Enhancing HGF activity has been proposed as a potential strategy to promote healthy aging and tissue repair.
Disease: Dysregulation of HGF signaling is associated with various diseases, including cancer, fibrosis, and inflammatory conditions. Understanding the role of HGF in these diseases can provide insights into their pathogenesis and lead to the development of novel therapeutic approaches.
