Growth Factors
Product List
RANK Human
RANK Human Recombinant
RANK Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 174 amino acids and having a molecular mass of 19.1kDa.
The RANK is purified by proprietary chromatographic techniques.
RANK Human, Sf9
RANK Human Recombinant, Sf9
sRANKL (158-316) Mouse
Soluble RANK Ligand (158-316 a.a) Mouse Recombinant
sRANKL Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 160 amino acids (158-316 a.a.) and having a molecular mass of 17.9kDa. sRANKL is purified by proprietary chromatographic techniques.
sRANKL Human
RANK Ligand Soluble Human Recombinant
sRANKL Human, GST
Soluble RANK Ligand Human Recombinant, GST tag
RANKL is purified by proprietary chromatographic techniques.
sRANKL Human, His
Soluble RANK Ligand Human Recombinant, His Tag
sRANKL Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 199 amino acids (140-317 a.a) and having a molecular mass of 22.3kDa.
sRANKL is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
sRANKL Mouse
RANK Ligand Soluble Mouse Recombinant
sRANKL Mouse Recombinant produced in E.coli is single, non-glycosylated, polypeptide chain containing 174 amino acids ( 143-316 a.a.) and having a total molecular mass of 19.9kDa. CD254 is purified by proprietary chromatographic techniques.
Introduction
Key Biological Properties: RANKL induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts, which are responsible for bone resorption . It also plays a role in immune responses and organogenesis .
Expression Patterns: RANKL is expressed in various tissues, including skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblasts, mammary gland epithelial cells, prostate, and pancreas .
Tissue Distribution: High protein expression of RANKL is detected in the lungs, thymus, and lymph nodes, while low expression is found in bone marrow, stomach, peripheral blood, spleen, placenta, leukocytes, heart, thyroid, and skeletal muscle .
Primary Biological Functions: RANKL is crucial for the development and activation of osteoclasts, which are essential for bone remodeling and resorption . It also plays a significant role in the immune system, including T cell and dendritic cell interactions .
Role in Immune Responses and Pathogen Recognition: RANKL is involved in the regulation of immune responses, including the activation of dendritic cells and the development of lymph nodes . It also contributes to the body’s defense mechanisms against pathogens .
Mechanisms with Other Molecules and Cells: RANKL interacts with its receptor RANK on the surface of osteoclast precursors, leading to their differentiation into mature osteoclasts . It also binds to osteoprotegerin (OPG), a decoy receptor that inhibits RANKL-RANK interactions .
Binding Partners and Downstream Signaling Cascades: The binding of RANKL to RANK activates several downstream signaling pathways, including the NF-κB, MAPK, and PI3K/Akt pathways . These pathways regulate the expression of genes involved in osteoclast differentiation and function .
Regulatory Mechanisms: The expression and activity of RANKL are regulated at multiple levels, including transcriptional regulation and post-translational modifications . Transcription factors such as NFATc1 and c-Fos play crucial roles in the transcriptional regulation of RANKL .
Post-Translational Modifications: RANKL undergoes various post-translational modifications, including glycosylation and proteolytic cleavage, which can affect its activity and stability .
Biomedical Research: RANKL is widely studied in the field of osteoimmunology, which explores the interactions between the immune system and bone metabolism .
Diagnostic Tools: RANKL levels can be measured as a biomarker for bone diseases such as osteoporosis and rheumatoid arthritis .
Therapeutic Strategies: Targeting the RANKL-RANK-OPG pathway has led to the development of therapeutic agents such as denosumab, a monoclonal antibody used to treat osteoporosis and bone metastases .
